(Q44172949)

30 November 2017

title

The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

polycystic kidney disease

13 May 2020

main subject

1 reference

4

Gideon Bollag

2 references

30 November 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

12

Kai-Uwe Eckardt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

author name string

Bjoern Buchholz

1

1 reference

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13 May 2020

Bernd Klanke

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

Gunnar Schley

3

1 reference

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13 May 2020

James Tsai

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

Sven Kroening

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

Daisuke Yoshihara

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

Darren P Wallace

8

1 reference

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13 May 2020

Bettina Kraenzlin

9

1 reference

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13 May 2020

Norbert Gretz

10

1 reference

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13 May 2020

Peter Hirth

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

Wanja M Bernhardt

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

29 July 2011

1 reference

Nephrology Dialysis Transplantation

30 November 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

issue

11

1 reference

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13 May 2020

page(s)

3458-3465

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease

13 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Src inhibition ameliorates polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

ERK and MMPs sequentially regulate distinct stages of epithelial tubule development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Involvement of hypoxia-inducible transcription factors in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Vasopressin directly regulates cyst growth in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Intracellular signaling via ERK/MAPK completes the pathway for tubulogenic fibronectin in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Everolimus in patients with autosomal dominant polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFR432

Increased water intake decreases progression of polycystic kidney disease in the PCK rat

21 January 2018

1 reference

12 December 2020

Signal transduction through MAP kinase cascades

1 reference

12 December 2020

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

1 reference

12 December 2020

Epithelial transport in polycystic kidney disease

1 reference

12 December 2020

MAPK signaling and the kidney

1 reference

12 December 2020

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells

1 reference

12 December 2020

Water for ADPKD? Probably, yes

1 reference

12 December 2020

Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease

1 reference

12 December 2020

Autosomal-dominant polycystic kidney disease in the rat

1 reference

12 December 2020

The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF

1 reference

12 December 2020

MAP kinase in situ activation atlas during Drosophila embryogenesis.

1 reference

12 December 2020

Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease

1 reference

12 December 2020

Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells

1 reference

12 December 2020

Identifiers

DOI

10.1093/NDT/GFR432

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6281052&resulttype=core&format=json

13 May 2020

1 reference