(Q44205869)

English

Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

scientific article published in November 2002

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scholarly article

1 reference

Europe PubMed Central

30 November 2017

Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Daniel A Linseman

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

Reid A Phelps

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

Ron J Bouchard

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

Shoshona S Le

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

Tracey A Laessig

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

Maria L McClure

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

Kim A Heidenreich

7

1 reference

Europe PubMed Central

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12 May 2020

language of work or name

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publication date

1 November 2002

1 reference

Europe PubMed Central

30 November 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

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12 May 2020

22

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

9287-9297

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

21

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial depolarization is not required for neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribozyme-mediated inhibition of caspase-3 protects cerebellar granule cells from apoptosis induced by serum-potassium deprivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target-related and intrinsic neuronal death in Lurcher mutant mice are both mediated by caspase-3 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cascade of caspase activation in potassium-deprived cerebellar granule neurons: targets for treatment with peptide and protein inhibitors of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breaking the mitochondrial barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of insulin-like growth factor genes in rat central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin-like growth factor I system in cerebellar degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic pathways: the roads to ruin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human caspases by peptide-based and macromolecular inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-21-09287.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758065&resulttype=core&format=json

12 May 2020

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