(Q44285130)

English

Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).

scientific article published on 24 May 2012

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Europe PubMed Central

PubMed publication ID

1 December 2017

Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD). (English)

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Europe PubMed Central

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1 December 2017

Alzheimer's disease

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3

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1 December 2017

Diego Muñoz-Torrero

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1 December 2017

author name string

M Ratia

1

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1 December 2017

L Giménez-Llort

2

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1 December 2017

B Pérez

5

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1 December 2017

M V Clos

6

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1 December 2017

A Badia

7

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1 December 2017

publication date

24 May 2012

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1 December 2017

Neurodegenerative Diseases

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11

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3

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129-140

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1 December 2017

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Interaction of a new potent anticholinesterasic compound (+/-)huprine X with muscarinic receptors in rat brain

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Potentiation effects of (+/-)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Behavioural effects and regulation of PKCalpha and MAPK by huprine X in middle aged mice

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid.

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Emotional instability but intact spatial cognition in adenosine receptor 1 knock out mice

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

ADAMs family members as amyloid precursor protein alpha-secretases

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

GSK3: a possible link between beta amyloid peptide and tau protein.

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Injections of tacrine and scopolamine into the nucleus accumbens: opposing effects of immediate vs delayed posttrial treatment on memory of an open field.

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Motor dysfunction produced by tacrine administration in rats

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Tetrahydroaminoacridine inhibits human and rat brain monoamine oxidase

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Regulation of amyloid precursor protein cleavage

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Acetylcholinesterase triggers the aggregation of PrP 106-126

1 reference

https://api.crossref.org/works/10.1159%2F000336427

21 January 2018

Identifiers

10.1159/000336427

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

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