(Q44285833)

1 December 2017

title

Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics (English)

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1 December 2017

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8

Wim Jiskoot

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1 December 2017

Maryam Ahmadi

1

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1 December 2017

Christine J Bryson

2

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1 December 2017

Edward A Cloake

3

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1 December 2017

Katie Welch

4

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1 December 2017

Vasco Filipe

5

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1 December 2017

Stefan Romeijn

6

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1 December 2017

Andrea Hawe

7

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1 December 2017

Matthew P Baker

9

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1 December 2017

Mark H Fogg

10

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1 December 2017

language of work or name

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1 April 2015

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1 December 2017

published in

Pharmaceutical Research

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1 December 2017

volume

32

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1 December 2017

issue

4

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1 December 2017

page(s)

1383-1394

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Role of repetitive antigen patterns for induction of antibodies against antibodies

1 December 2017

cites work

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An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics

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Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro

21 January 2018

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Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

21 January 2018

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Fluorescence single particle tracking for the characterization of submicron protein aggregates in biological fluids and complex formulations

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Detection and characterization of subvisible aggregates of monoclonal IgG in serum

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IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition

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Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus

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IL-21 is an immune activator that also mediates suppression via IL-10.

21 January 2018

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Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE.

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Preclinical models used for immunogenicity prediction of therapeutic proteins

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Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responses

21 January 2018

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12 December 2020

Immunogenicity of different brands of human insulin and rapid-acting insulin analogs in insulin-naïve children with type 1 diabetes

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12 December 2020

Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma

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12 December 2020

Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells

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12 December 2020

Chemical stability of insulin. 1. Hydrolytic degradation during storage of pharmaceutical preparations

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12 December 2020

The influence of antigen organization on B cell responsiveness

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12 December 2020

Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes

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12 December 2020

Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

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12 December 2020

Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials

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12 December 2020

IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses

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12 December 2020

Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins

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12 December 2020

Induction of tolerance by IL-10-treated dendritic cells

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12 December 2020

Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo

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12 December 2020

10.1007/S11095-014-1541-X

Identifiers

DOI

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1 December 2017

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