(Q44295644)

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The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

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1 reference

Europe PubMed Central

1 December 2017

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart (English)

1 reference

Europe PubMed Central

1 December 2017

Cristine Alves da Costa

1

1 reference

Europe PubMed Central

1 December 2017

Frédéric Checler

4

1 reference

Europe PubMed Central

1 December 2017

author name string

Mark P Mattson

2

1 reference

Europe PubMed Central

1 December 2017

Karine Ancolio

3

1 reference

Europe PubMed Central

1 December 2017

language of work or name

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publication date

29 January 2003

1 reference

Europe PubMed Central

1 December 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

1 December 2017

278

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Europe PubMed Central

1 December 2017

14

1 reference

Europe PubMed Central

1 December 2017

12064-12069

1 reference

Europe PubMed Central

1 December 2017

Presenilins and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Presenilins: structural aspects and posttranslational events.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

New frontiers in Alzheimer's disease genetics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Distinct processing of endogenous and overexpressed recombinant presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Presenilins: multifunctional proteins involved in Alzheimer's disease pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Presenilins are processed by caspase-type proteases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Presenilin-1 is processed into two major cleavage products in neuronal cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212379200

21 January 2018

Identifiers

10.1074/JBC.M212379200

1 reference

Europe PubMed Central

1 December 2017

1 reference

Europe PubMed Central

1 December 2017

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