(Q44301763)

1 December 2017

title

Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation (English)

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1 December 2017

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Kun Ling Ma

1

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1 December 2017

Jing Liu

2

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1 December 2017

Chang Xian Wang

3

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1 December 2017

Jie Ni

4

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1 December 2017

Yang Zhang

5

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1 December 2017

Yu Wu

6

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1 December 2017

Lin Li Lv

7

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1 December 2017

Xiong Zhong Ruan

8

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1 December 2017

Bi Cheng Liu

9

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1 December 2017

publication date

25 September 2013

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1 December 2017

published in

Cardiovascular Research

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1 December 2017

volume

100

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1 December 2017

issue

3

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1 December 2017

page(s)

450-460

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Atherosclerosis as an inflammatory disease

1 December 2017

cites work

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TOR signaling in growth and metabolism

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Upstream and downstream of mTOR

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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Connecting mTORC1 signaling to SREBP-1 activation

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Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

21 January 2018

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The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

21 January 2018

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Positive feedback loop between PI3K-Akt-mTORC1 signaling and the lipogenic pathway boosts Akt signaling: induction of the lipogenic pathway by a melanoma antigen.

21 January 2018

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Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

21 January 2018

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Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

21 January 2018

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Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation

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Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway

21 January 2018

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M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

21 January 2018

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Signaling by target of rapamycin proteins in cell growth control

21 January 2018

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Mammalian target of rapamycin as a therapeutic target in leukemia

21 January 2018

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Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties

21 January 2018

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Hyperphosphorylation regulates the activity of SREBP1 during mitosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/CVR/CVT203

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1 December 2017

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