(Q44351142)

2 December 2017

title

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics (English)

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2 December 2017

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Cullen L Schmid

1

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2 December 2017

Nicole M Kennedy

2

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2 December 2017

Nicolette C Ross

3

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2 December 2017

Kimberly M Lovell

4

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2 December 2017

Zhizhou Yue

5

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2 December 2017

Jenny Morgenweck

6

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2 December 2017

Michael D Cameron

7

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2 December 2017

Thomas D Bannister

8

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2 December 2017

Laura M Bohn

9

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2 December 2017

language of work or name

English

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publication date

1 November 2017

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2 December 2017

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2 December 2017

volume

171

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2 December 2017

issue

5

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2 December 2017

page(s)

1165-1175.e13

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Addressing the Fentanyl Threat to Public Health

2 December 2017

cites work

1 reference

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27 August 2018

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27 August 2018

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Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

27 August 2018

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Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.

27 August 2018

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27 August 2018

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A novel method for analyzing extremely biased agonism at G protein-coupled receptors

27 August 2018

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Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

27 August 2018

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Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists

27 August 2018

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Enhancement of morphine analgesia and prevention of morphine tolerance by downregulation of β-arrestin 2 with antigene RNAs in mice

27 August 2018

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Development of functionally selective, small molecule agonists at kappa opioid receptors

27 August 2018

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Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons

27 August 2018

1 reference

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A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

27 August 2018

1 reference

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14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects

27 August 2018

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A simple method for quantifying functional selectivity and agonist bias

27 August 2018

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Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.

27 August 2018

1 reference

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Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation.

27 August 2018

1 reference

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Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter

27 August 2018

1 reference

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Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

27 August 2018

1 reference

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Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.

27 August 2018

1 reference

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

27 August 2018

1 reference

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Mu opioid receptor regulation and opiate responsiveness

27 August 2018

1 reference

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Morphine side effects in beta-arrestin 2 knockout mice

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731250

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

27 August 2018

1 reference

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

27 August 2018

1 reference

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Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice

27 August 2018

1 reference

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Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

27 August 2018

1 reference

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Enhanced morphine analgesia in mice lacking beta-arrestin 2

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731250

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

27 August 2018

1 reference

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Operational models of pharmacological agonism.

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731250

Bezitramide (R 4845), a new potent and orally long-acting analgesic compound

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731250

27 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/29149605

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2017.10.035

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2 December 2017

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