(Q44400938)

2 December 2017

Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases (English)

1 reference

2 December 2017

0 references

1

Gitanjali Yadav

1 reference

2 December 2017

Rajesh S Gokhale

2

1 reference

PubMed ID

12691745

2 December 2017

Debasisa Mohanty

series ordinal

3

1 reference

PubMed ID

12691745

2 December 2017

language of work or name

English

0 references

publication date

1 April 2003

1 reference

Journal of Molecular Biology

2 December 2017

1 reference

2 December 2017

328

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2 December 2017

335-363

1 reference

2 December 2017

2

1 reference

Combinatorial biosynthesis of 'unnatural' natural products: the polyketide example

2 December 2017

1 reference

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Production of ‘hybrid’ antibiotics by genetic engineering

7 January 2021

1 reference

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Polyketide synthesis: prospects for hybrid antibiotics

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

inferred from DOI database lookup

7 January 2021

based on heuristic

Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

1 reference

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Genetic Contributions to Understanding Polyketide Synthases

7 January 2021

1 reference

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Dissecting and exploiting intermodular communication in polyketide synthases

7 January 2021

1 reference

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Role of linkers in communication between protein modules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Structural control of polyketide formation in plant-specific polyketide synthases

7 January 2021

1 reference

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Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

7 January 2021

1 reference

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Antibiotic activity of polyketide products derived from combinatorial biosynthesis: implications for directed evolution

7 January 2021

1 reference

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Tolerance and specificity of polyketide synthases

7 January 2021

1 reference

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Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

7 January 2021

1 reference

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Generation of polyketide libraries via combinatorial biosynthesis

7 January 2021

1 reference

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Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

7 January 2021

1 reference

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Engineered intermodular and intramodular polyketide synthase fusions

7 January 2021

1 reference

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Modular organization of genes required for complex polyketide biosynthesis

7 January 2021

1 reference

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An erythromycin analog produced by reprogramming of polyketide synthesis

7 January 2021

1 reference

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Novel avermectins produced by mutational biosynthesis.

7 January 2021

1 reference

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A hybrid modular polyketide synthase obtained by domain swapping

7 January 2021

1 reference

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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

7 January 2021

1 reference

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Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

7 January 2021

1 reference

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Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

7 January 2021

1 reference

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Engineering broader specificity into an antibiotic-producing polyketide synthase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

7 January 2021

1 reference

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Polyketide biosynthesis: a millennium review

7 January 2021

1 reference

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Harnessing the biosynthetic code: combinations, permutations, and mutations

7 January 2021

1 reference

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The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

7 January 2021

1 reference

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CDD: a database of conserved domain alignments with links to domain three-dimensional structure

7 January 2021

1 reference

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The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

7 January 2021

1 reference

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6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

7 January 2021

1 reference

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Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis

7 January 2021

1 reference

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Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.

7 January 2021

1 reference

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Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.

7 January 2021

1 reference

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Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Identification and sequence analysis of the genes encoding a polyketide synthase required for pyoluteorin biosynthesis in Pseudomonas fluorescens Pf-5.

7 January 2021

1 reference

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New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.

7 January 2021

1 reference

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GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences

7 January 2021

1 reference

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Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

7 January 2021

1 reference

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Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

inferred from DOI database lookup

7 January 2021

based on heuristic

Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes

7 January 2021

1 reference

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The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase

7 January 2021

1 reference

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A Bacillus subtilis large ORF coding for a polypeptide highly similar to polyketide synthases

7 January 2021

1 reference

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Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria

7 January 2021

1 reference

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Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

7 January 2021

1 reference

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Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes

7 January 2021

1 reference

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The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900232-8

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

7 January 2021

1 reference

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The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

7 January 2021

1 reference

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Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea

7 January 2021

1 reference

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Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin

7 January 2021

1 reference

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Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides.

7 January 2021

1 reference

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A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis

7 January 2021

1 reference

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Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

7 January 2021

1 reference

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Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

7 January 2021

1 reference

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The tylosin-biosynthetic genes of Streptomyces fradiae

7 January 2021

1 reference

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Database resources of the National Center for Biotechnology Information: 2002 update

7 January 2021

1 reference

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Basic local alignment search tool

7 January 2021

1 reference

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The Pfam protein families database

7 January 2021

1 reference

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

7 January 2021

1 reference

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7 January 2021

The Protein Data Bank

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An evolutionary trace method defines binding surfaces common to protein families

7 January 2021

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Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool

7 January 2021

1 reference

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Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system.

7 January 2021

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10.1016/S0022-2836(03)00232-8

7 January 2021

Identifiers

DOI

1 reference

2 December 2017

1 reference

PubMed ID

12691745