(Q44406747)

2 December 2017

The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition (English)

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2 December 2017

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8

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2 December 2017

Xiao-Feng Le

1

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2 December 2017

Francois-Xavier Claret

2

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2 December 2017

Amy Lammayot

3

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2 December 2017

Ling Tian

4

1 reference

2 December 2017

Deepa Deshpande

5

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2 December 2017

Ruth LaPushin

6

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2 December 2017

Ana M Tari

7

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2 December 2017

language of work or name

English

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publication date

16 April 2003

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Journal of Biological Chemistry

2 December 2017

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2 December 2017

278

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2 December 2017

23441-23450

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2 December 2017

26

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Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

2 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Untangling the ErbB signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

The EGF receptor family as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Translational control of p27Kip1 accumulation during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Protein destruction: adapting roles for Cks proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Regulation of the G1 to S transition by the ubiquitin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300848200

21 January 2018

Identifiers

DOI

10.1074/JBC.M300848200

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2 December 2017

1 reference