(Q44424097)

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Genetically Modified NT2N Human Neuronal Cells Mediate Long-Term Gene Expression as CNS Grafts In Vivo and Improve Functional Cognitive Outcome Following Experimental Traumatic Brain Injury

scientific article published on April 1, 2003

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scholarly article

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Europe PubMed Central

2 December 2017

Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury (English)

1 reference

Europe PubMed Central

2 December 2017

Genetically Modified NT2N Human Neuronal Cells Mediate Long-Term Gene Expression as CNS Grafts In Vivo and Improve Functional Cognitive Outcome Following Experimental Traumatic Brain Injury (English)

1 reference

10.1093/JNEN/62.4.368

https://api.crossref.org/works/10.1093/JNEN/62.4.368

29 December 2023

traumatic brain injury

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1 reference

10.1093/JNEN/62.4.368

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29 December 2023

John Q. Trojanowski

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object named as

John Q Trojanowski

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author name string

Luca Longhi

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Scott Fujimoto

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Deborah J. Watson

1

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29 December 2023

Edward B. Lee

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29 December 2023

Carl T. Fulp

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29 December 2023

Nicolas C. Royo

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29 December 2023

Marco A. Passini

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29 December 2023

Virginia M. Y. Lee

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29 December 2023

Tracy K. McIntosh

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29 December 2023

John H. Wolfe

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publication date

1 April 2003

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full work available at URL

https://academic.oup.com/jnen/article-pdf/62/4/368/9553965/62-4-368.pdf

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http://apt.allenpress.com/aptonline/?request=get-abstract&issn=0022-3069&volume=062&issue=04&page=0368

online access status

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29 December 2023

Journal of Neuropathology & Experimental Neurology

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62

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4

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368-380

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2 December 2017

Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

The properties of hNT cells following transplantation into the subventricular zone of the neonatal forebrain

1 reference

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21 January 2018

Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain

1 reference

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21 January 2018

Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain

1 reference

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21 January 2018

Embryonic stem cells go dopaminergic

1 reference

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21 January 2018

Cell replacement therapies for central nervous system disorders.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Long-term integration and neuronal differentiation of human embryonal carcinoma cells (NTera-2) transplanted into the caudoputamen of nude mice

1 reference

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21 January 2018

Transplantation of cultured human neuronal cells for patients with stroke

1 reference

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21 January 2018

Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation

1 reference

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21 January 2018

Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats

1 reference

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21 January 2018

Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease

1 reference

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21 January 2018

Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Serial [18F] fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Vaccinia virus serves as an efficient vector for expressing heterologous proteins in human NTera 2 neurons

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Anti-human immunodeficiency virus type 1 gene therapy in human central nervous system-based cells: an initial approach against a potential viral reservoir

1 reference

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21 January 2018

Self-inactivating lentiviral vectors with U3 and U5 modifications.

1 reference

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21 January 2018

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Human neuron-committed teratocarcinoma NT2 cell line has abnormal ND10 structures and is poorly infected by herpes simplex virus type 1.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Retinoic acid induction of calcium channel expression in human NT2N neurons

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Acetylcholinesterase expression in NTera 2 human neuronal cells: a model for developmental expression in the nervous system

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Functional synapses are formed between human NTera2 (NT2N, hNT) neurons grown on astrocytes

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Human NT2 neurons express a large variety of neurotransmission phenotypes in vitro

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Gene therapy using hematopoietic stem cells: Sisyphus approaches the crest

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Hippocampally dependent and independent chronic spatial navigational deficits following parasagittal fluid percussion brain injury in the rat.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Traumatic brain injury in the developing rat: effects of maturation on Morris water maze acquisition

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Neurobehavioral outcome of closed head injury: implications for clinical trials

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Cognitive function outcomes after traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Nerve growth factor attenuates cholinergic deficits following traumatic brain injury in rats.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.4.368

21 January 2018

Bcl-xL protects adult septal cholinergic neurons from axotomized cell death

1 reference

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21 January 2018

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

2

1 reference

10.1093/JNEN/62.4.368

https://api.crossref.org/works/10.1093/JNEN/62.4.368

29 December 2023

Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins.

4

1 reference

10.1093/JNEN/62.4.368

https://api.crossref.org/works/10.1093/JNEN/62.4.368

29 December 2023

Differential effects of spinal cord gray and white matter on process outgrowth from grafted human NTERA2 neurons (NT2N, hNT)

16

1 reference

10.1093/JNEN/62.4.368

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Neural transplantation of hNT neurons for Huntington's disease

17

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10.1093/JNEN/62.4.368

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29 December 2023

Expression of foreign proteins in a human neuronal system

29

1 reference

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29 December 2023

GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells.

41

1 reference

10.1093/JNEN/62.4.368

https://api.crossref.org/works/10.1093/JNEN/62.4.368

29 December 2023

Retinoic acid induces cholinergic differentiation of NTera 2 human embryonal carcinoma cells

42

1 reference

10.1093/JNEN/62.4.368

https://api.crossref.org/works/10.1093/JNEN/62.4.368

29 December 2023

Neurotrophin gene therapy in CNS models of trauma and degeneration

59

1 reference

10.1093/JNEN/62.4.368

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29 December 2023

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

61

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10.1093/JNEN/62.4.368

https://api.crossref.org/works/10.1093/JNEN/62.4.368

29 December 2023

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10.1093/JNEN/62.4.368

1 reference

Europe PubMed Central

2 December 2017

1 reference

Europe PubMed Central

2 December 2017

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