(Q44533735)

English

A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates

scientific article published in August 2003

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scholarly article

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Europe PubMed Central

3 December 2017

A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates (English)

1 reference

Europe PubMed Central

3 December 2017

Curt M. Breneman

3

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Curt Breneman

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author name string

Dmitri Zagorevskii

1

1 reference

Europe PubMed Central

3 December 2017

Minghu Song

2

1 reference

Europe PubMed Central

3 December 2017

Curt Breneman

3

1 reference

Europe PubMed Central

3 December 2017

Yang Yuan

4

1 reference

Europe PubMed Central

3 December 2017

Tarra Fuchs

5

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Europe PubMed Central

3 December 2017

Kent S Gates

6

1 reference

Europe PubMed Central

3 December 2017

C Michael Greenlief

7

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Europe PubMed Central

3 December 2017

publication date

1 August 2003

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Europe PubMed Central

3 December 2017

Journal of the American Society for Mass Spectrometry

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Europe PubMed Central

3 December 2017

14

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Europe PubMed Central

3 December 2017

881-892

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Europe PubMed Central

3 December 2017

8

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Europe PubMed Central

3 December 2017

https://scigraph.springernature.com/pub.10.1016/s1044-0305(03)00334-9

0 references

Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1044-0305%2803%2900334-9

21 January 2018

Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1044-0305%2803%2900334-9

21 January 2018

Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-0305%2803%2900334-9

21 January 2018

3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

1 reference

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21 January 2018

Density-functional thermochemistry. III. The role of exact exchange

1 reference

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21 January 2018

Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density

1 reference

https://api.crossref.org/works/10.1016%2FS1044-0305%2803%2900334-9

21 January 2018

Modeling the action of an antitumor drug: a density functional theory study of the mechanism of tirapazamine

1 reference

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21 January 2018

An experimental study of hypervalent molecular clusters by neutralized ion beam spectroscopy: ammonium-ammonia (NH4(NH3)n) and deuterated ammonium-ammonia (ND4(ND3)n)

1 reference

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21 January 2018

The one-electron reduction potential of 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine): a hypoxia-selective bioreductive drug

1 reference

https://api.crossref.org/works/10.1016%2FS1044-0305%2803%2900334-9

21 January 2018

Direct evidence for bimodal DNA damage induced by tirapazamine

1 reference

https://api.crossref.org/works/10.1016%2FS1044-0305%2803%2900334-9

21 January 2018

Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions

1 reference

https://api.crossref.org/works/10.1016%2FS1044-0305%2803%2900334-9

21 January 2018

Studies of unusual simple molecules by neutralization-reionization mass spectrometry

1 reference

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21 January 2018

Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12892912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12892912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual action of tirapazamine in the induction of DNA strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/12892912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12892912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S1044-0305(03)00334-9

1 reference

Europe PubMed Central

3 December 2017

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1 reference

Europe PubMed Central

3 December 2017

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