(Q44536820)

English

Validation of In Vitro Cell-Based Human Blood−Brain Barrier Model Using Clinical Positron Emission Tomography Radioligands To Predict In Vivo Human Brain Penetration

scientific article published on September 15, 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Validation of in vitro cell-based human blood-brain barrier model using clinical positron emission tomography radioligands to predict in vivo human brain penetration (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Validation of In Vitro Cell-Based Human Blood−Brain Barrier Model Using Clinical Positron Emission Tomography Radioligands To Predict In Vivo Human Brain Penetration (English)

1 reference

10.1021/MP1002366

https://api.crossref.org/works/10.1021/MP1002366

2 July 2024

blood–brain barrier

1 reference

based on heuristic

inferred from title

positron emission tomography

1 reference

based on heuristic

inferred from title

neurological models

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20795735

2 July 2024

author name string

Aloïse Mabondzo

1

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Michel Bottlaender

2

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Anne-Cécile Guyot

3

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Katya Tsaouin

4

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Jean Robert Deverre

5

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Praveen V. Balimane

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20795735

2 July 2024

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publication date

15 September 2010

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Europe PubMed Central

PubMed publication ID

3 December 2017

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/mp1002366

1 reference

10.1021/MP1002366

https://api.crossref.org/works/10.1021/MP1002366

2 July 2024

Molecular Pharmaceutics

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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Europe PubMed Central

PubMed publication ID

3 December 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

1805-1815

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

1 reference

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Can the pharmaceutical industry reduce attrition rates?

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Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology.

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Cultured vascular endothelial cells of the brain.

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A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

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Porcine brain microvessel endothelial cells as an in vitro model to predict in vivo blood-brain barrier permeability

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Evaluation of drug penetration into the brain: a double study by in vivo imaging with positron emission tomography and using an in vitro model of the human blood-brain barrier.

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Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors

12

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Synthesis of ethyl 8-fluoro-5,6-dihydro5- [11C]methyl-6-oxo-4H-imidazo[1,5-a] [1,4]benzodiazepine-3-carboxylate (RO 15.1788-11C): A specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography

14

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Synthesis and in vivo imaging properties of [11C]befloxatone: a novel highly potent positron emission tomography ligand for mono-amine oxidase-A.

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Combination of tenofovir and emtricitabine plus efavirenz: in vitro modulation of ABC transporter and intracellular drug accumulation.

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Efflux transport systems for organic anions and cations at the blood-CSF barrier

19

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Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier

20

1 reference

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Journal of Pharmacology and Experimental Therapeutics

21

286

890

author name string

Kitazawa T.

publication date

1998

1 reference

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Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.

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Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain

24

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Endothelin-1 reduces p-glycoprotein transport activity in an in vitro model of human adult blood-brain barrier

25

1 reference

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Journal of Pharmacology and Experimental Therapeutics

26

253

884

author name string

Pardridge W. M.

publication date

1990

1 reference

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Modeling analysis of [11C]flumazenil kinetics studied by PET: application to a critical study of the equilibrium approaches.

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Quantification of cerebral nicotinic acetylcholine receptors by PET using 2-[18F]fluoro-A-85380 and the multiinjection approach

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In vivo detection of striatal dopamine release during reward: a PET study with [(11)C]raclopride and a single dynamic scan approach

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1 reference

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Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol.

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In vivo quantification of monoamine oxidase A in baboon brain: a PET study using [(11)C]befloxatone and the multi-injection approach

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Kinetics and modeling of L-6-[18F]fluoro-dopa in human positron emission tomographic studies

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Regional kinetic constants and cerebral metabolic rate for glucose in normal human volunteers determined by dynamic positron emission tomography of [18F]-2-fluoro-2-deoxy-D-glucose

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Comparison of ABC transporter modulation by atazanavir in lymphocytes and human brain endothelial cells: ABC transporters are involved in the atazanavir-limited passage across an in vitro human model of the blood-brain barrier

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ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

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Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

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Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

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Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

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On the rate and extent of drug delivery to the brain.

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Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery

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Current industrial practices of assessing permeability and P-glycoprotein interaction

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Identifiers

10.1021/MP1002366

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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