(Q44539052)

English

Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries.

scientific article published in August 2003

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6 November 2019

Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries (English)

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6 November 2019

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6 November 2019

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Rica Pargas Ficco

2

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6 November 2019

David Dain

3

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6 November 2019

Mark Ginski

4

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6 November 2019

Susan Lautar

5

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6 November 2019

Kathy Lee-Wisdom

6

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6 November 2019

Shi Liang

7

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6 November 2019

Qian Lin

8

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6 November 2019

May X-C Lu

9

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6 November 2019

Lisa Morgan

10

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6 November 2019

Bert Thomas

11

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6 November 2019

Lawrence R Williams

12

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6 November 2019

Jie Zhang

13

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6 November 2019

Yinong Zhou

14

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6 November 2019

Vincent J Kalish

15

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6 November 2019

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1 August 2003

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6 November 2019

Bioorganic & Medicinal Chemistry

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6 November 2019

11

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6 November 2019

17

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6 November 2019

3695-3707

1 reference

Europe PubMed Central

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6 November 2019

Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis.

1 reference

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7 January 2021

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Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis

1 reference

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7 January 2021

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

1 reference

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7 January 2021

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Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.

1 reference

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7 January 2021

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Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching.

1 reference

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7 January 2021

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DNA repair: PARP - another guardian angel?

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7 January 2021

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Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia

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7 January 2021

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Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia

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7 January 2021

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Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

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7 January 2021

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Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion

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Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase

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Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.

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Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation

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7 January 2021

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Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP).

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Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors.

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Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase

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Carboxamide group conformation in the nicotinamide and thiazole-4-carboxamide rings: implications for enzyme binding

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Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.

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Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure

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Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives

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Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.

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7 January 2021

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Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock

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The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

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Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling

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Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis

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Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates

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Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells

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Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3.

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Identifiers

10.1016/S0968-0896(03)00333-X

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6 November 2019

PubMed publication ID

1 reference

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6 November 2019

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