(Q44610013)

4 December 2017

title

Localization of an antithrombin exosite that promotes rapid inhibition of factors Xa and IXa dependent on heparin activation of the serpin (English)

1 reference

4 December 2017

Localization of an Antithrombin Exosite That Promotes Rapid Inhibition of Factors Xa and IXa Dependent on Heparin Activation of the Serpin (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M309266200

19 March 2024

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14532267

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M309266200

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M309266200

19 March 2024

author name string

Gonzalo Izaguirre

1

1 reference

4 December 2017

Weiqing Zhang

2

1 reference

4 December 2017

Richard Swanson

3

1 reference

4 December 2017

Tina Bedsted

4

1 reference

4 December 2017

Steven T. Olson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14532267

19 March 2024

language of work or name

English

0 references

publication date

7 October 2003

1 reference

full work available at URL

4 December 2017

http://www.jbc.org/article/S0021925820754049/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14532267

https://api.elsevier.com/content/article/PII:S0021925820754049?httpAccept=text/xml

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M309266200

https://api.elsevier.com/content/article/PII:S0021925820754049?httpAccept=text/plain

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M309266200

https://syndication.highwire.org/content/doi/10.1074/jbc.M309266200

19 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M309266200

Journal of Biological Chemistry

19 March 2024

published in

1 reference

4 December 2017

volume

278

1 reference

4 December 2017

issue

51

1 reference

4 December 2017

page(s)

51433-51440

1 reference

Complete antithrombin deficiency in mice results in embryonic lethality

4 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Serpin structure, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Characterization of specific receptors for vasopressin in the pituitary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Further characterization of the antithrombin-binding sequence in heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Molecular mapping of the heparin-binding exosite of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

The anticoagulant activation of antithrombin by heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a β-like variant in baculovirus-infected insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

The Size and Shape of Human and Bovine Antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Unexpected binding mode of tick anticoagulant peptide complexed to bovine factor Xa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Carbohydrate isoforms of antithrombin variant N135Q with different heparin affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Mechanisms of glycosaminoglycan activation of the serpins in hemostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Insight into residues critical for antithrombin function from analysis of an expanded database of sequences that includes frog, turtle, and ostrich antithrombins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Structure of beta-antithrombin and the effect of glycosylation on antithrombin's heparin affinity and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Role of basic residues of the autolysis loop in the catalytic function of factor Xa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Contribution of Basic Residues of the Autolysis Loop to the Substrate and Inhibitor Specificity of Factor IXa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Localization of the heparin binding exosite of factor IXa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Activation of prothrombin with (taipan snake) venom

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309266200

Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

21 January 2018

11

1 reference

https://api.crossref.org/works/10.1074/JBC.M309266200

19 March 2024

Identifiers

1 reference

4 December 2017

1 reference