(Q35181635)

7 August 2017

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title

Mechanisms of glycosaminoglycan activation of the serpins in hemostasis (English)

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7 August 2017

J A Huntington

1

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7 August 2017

publication date

1 July 2003

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Journal of Thrombosis and Haemostasis

7 August 2017

published in

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7 August 2017

volume

1

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7 August 2017

issue

7

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7 August 2017

page(s)

1535-1549

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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

21 January 2018

Serpins in prokaryotes

1 reference

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Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

The structure of active serpin 1K from Manduca sexta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Conformational changes in thrombin when complexed by serpins

21 January 2018

1 reference

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Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

A player of many parts: the spotlight falls on thrombin's structure.

21 January 2018

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Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Structure and biological interactions of heparin and heparan sulfate

21 January 2018

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The antithrombin-binding sequence of heparin

21 January 2018

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The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence Chemical and13C nuclear-magnetic-resonance studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding

21 January 2018

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The anticoagulant activation of antithrombin by heparin

21 January 2018

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Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

The structure of a Michaelis serpin-protease complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Mobile reactive centre of serpins and the control of thrombosis

21 January 2018

1 reference

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Serpins and regulation of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Inhibitory mechanism of serpins. Identification of steps involving the active-site serine residue of the protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

Heparin cofactor II activity in plasma: application of an automated assay method to the study of a normal adult population

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1538-7836.2003.00305.X

10.1046/J.1538-7836.2003.00305.X

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference