(Q44640417)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

The contribution of the exosite residues of plasminogen activator inhibitor-1 to proteinase inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

author name string

Catherine A Ibarra

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Grant E Blouse

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Joseph D Shore

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

language of work or name

English

0 references

publication date

31 October 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

20 December 2019

number of pages

8

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

volume

279

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

page(s)

3643-3650

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001.

20 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Structural basis for serpin inhibitor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Major proteinase movement upon stable serpin-proteinase complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Serpin structure, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Serpin-resistant mutants of human tissue-type plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

A concerted structural transition in the plasminogen activator inhibitor-1 mechanism of inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Mutation of the Highly Conserved Tryptophan in the Serpin Breach Region Alters the Inhibitory Mechanism of Plasminogen Activator Inhibitor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Dynamic structural and functional relationships in recombinant plasminogen activator inhibitor-1 (rPAI-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Mechanisms of conversion of plasminogen activator inhibitor 1 from a suicide inhibitor to a substrate by monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

The F-helix of serpins plays an essential, active role in the proteinase inhibition mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

The structure of a Michaelis serpin-protease complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Glycosaminoglycans in human retinoblastoma cells: heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

Development of a novel recombinant serpin with potential antithrombotic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310601200

21 January 2018

Identifiers

DOI

10.1074/JBC.M310601200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14594804%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference