(Q44068347)

29 November 2017

title

The F-helix of serpins plays an essential, active role in the proteinase inhibition mechanism (English)

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29 November 2017

Peter G W Gettins

1

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29 November 2017

language of work or name

English

0 references

publication date

1 July 2002

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29 November 2017

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29 November 2017

volume

523

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29 November 2017

issue

1-3

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29 November 2017

page(s)

2-6

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On the size of the active site in proteases. I. Papain

29 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

The reaction of serpins with proteinases involves important enthalpy changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Heterogeneity in serpin-protease complexes as demonstrated by differences in the mechanism of complex breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

The structure of a Michaelis serpin-protease complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Loop-inserted and thermostabilized structure of P1-P1' cleaved ovalbumin mutant R339T

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

The P6−P2 Region of Serpins Is Critical for Proteinase Inhibition and Complex Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Influence of the P5 residue on alpha1-proteinase inhibitor mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

The structure of a serpin-protease complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Distortion of the active site of chymotrypsin complexed with a serpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Change in environment of the P1 side chain upon progression from the Michaelis complex to the covalent serpin-proteinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Properties of thrombin- and elastase-modified human antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Formation of a noncovalent serpin-proteinase complex involves no conformational change in the serpin. Use of 1H-15N HSQC NMR as a sensitive nonperturbing monitor of conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Role of the P6-P3' region of the serpin reactive loop in the formation and breakdown of the inhibitory complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Topology of the stable serpin-protease complexes revealed by an autoantibody that fails to react with the monomeric conformers of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902924-1

Molecular evolution of plasminogen activator inhibitor-1 functional stability

21 January 2018

1 reference

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10.1016/S0014-5793(02)02924-1

7 January 2021

Identifiers

DOI

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29 November 2017

1 reference