(Q44738170)

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Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).

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5 December 2017

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75). (English)

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Europe PubMed Central

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5 December 2017

Jonas Demeulemeester

6

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5 December 2017

author name string

H Méreau

1

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Europe PubMed Central

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5 December 2017

J De Rijck

2

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Europe PubMed Central

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5 December 2017

K Cermáková

3

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Europe PubMed Central

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5 December 2017

A Kutz

4

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Europe PubMed Central

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5 December 2017

S Juge

5

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5 December 2017

R Gijsbers

7

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Europe PubMed Central

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5 December 2017

F Christ

8

1 reference

Europe PubMed Central

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5 December 2017

Z Debyser

9

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5 December 2017

J Schwaller

10

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5 December 2017

publication date

15 January 2013

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5 December 2017

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5 December 2017

27

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5 December 2017

6

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5 December 2017

1245-1253

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Europe PubMed Central

PubMed publication ID

5 December 2017

https://scigraph.springernature.com/pub.10.1038/leu.2013.10

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The MLL recombinome of acute leukemias

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Mechanisms of leukemogenesis by MLL fusion proteins

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

The molecular biology of mixed lineage leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

The super elongation complex (SEC) and MLL in development and disease

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Therapeutic targeting of MLL.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

An essential role for LEDGF/p75 in HIV integration

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.10

21 January 2018

Identifiers

10.1038/LEU.2013.10

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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