(Q44774846)

English

Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate

scientific article published on 23 February 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

1 reference

based on heuristic

inferred from title

4

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

author name string

Amal El Fadili

1

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Christoph Kündig

2

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Gaétan Roy

3

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

language of work or name

0 references

publication date

23 February 2004

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

6 December 2017

279

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

18575-18582

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Pterin transport and metabolism in Leishmania and related trypanosomatid parasites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Characterization of the folylpolyglutamate synthetase gene and polyglutamylation of folates in the protozoan parasite Leishmania

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Nutritional requirements of wild-type and folate transport-deficient Leishmania donovani for pterins and folates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Gene amplification in Leishmania

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

New mechanisms of drug resistance in parasitic protozoa

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Trypanosoma cruzi genome encodes a pteridine reductase 2 protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs in other species

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Glutamyl hydrolase. pharmacological role and enzymatic characterization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

New perspectives on folate catabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Pteridine Requirement of the HemoflagellateLeishmania tarentolae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

The growth and nutrition of Crithidia fasciculata

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Folylpolyglutamates in Leishmania major

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Studying neuronal peptide release and secretory granule dynamics with green fluorescent protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Radioassay of the folate-hydrolyzing enzyme activity, and the distribution of the enzyme in biological cells and tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400652200

21 January 2018

Identifiers

10.1074/JBC.M400652200

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

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