(Q44857393)

English

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions

scientific article published on 14 April 2004

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scholarly article

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Europe PubMed Central

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6 December 2017

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions (English)

1 reference

Europe PubMed Central

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6 December 2017

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François Diederich

10

object named as

François Diederich

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6 December 2017

9

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Klaus Müller

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6 December 2017

author name string

Jacob Olsen

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6 December 2017

Paul Seiler

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6 December 2017

Björn Wagner

3

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6 December 2017

Holger Fischer

4

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6 December 2017

Thomas Tschopp

5

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6 December 2017

Ulrike Obst-Sander

6

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6 December 2017

David W Banner

7

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6 December 2017

Manfred Kansy

8

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6 December 2017

publication date

14 April 2004

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6 December 2017

Organic and Biomolecular Chemistry

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6 December 2017

2

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6 December 2017

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6 December 2017

1339-1352

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6 December 2017

Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer

1 reference

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Metabolism of fluorine-containing drugs

1 reference

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A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions

1 reference

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Synthesis and SAR of thrombin inhibitors incorporating a novel 4-amino-morpholinone sscaffold: analysis of X-ray crystal structure of enzyme inhibitor complex

1 reference

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21 January 2018

Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones

1 reference

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21 January 2018

Structure-based design of novel potent nonpeptide thrombin inhibitors

1 reference

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Electronic effects in the interaction of para-substituted benzamidines with trypsin: the involvement of the pi-electronic density at the central atom of the substituent in binding

1 reference

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Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors

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Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position

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Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

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Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide

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Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.

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3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency

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Recent Advances in Azomethine Ylide Chemistry

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Interactions with aromatic rings in chemical and biological recognition

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Organic Fluorine Hardly Ever Accepts Hydrogen Bonds

1 reference

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The hydrogen bond in the solid state

1 reference

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Hydrogen bridges in crystal engineering: interactions without borders

1 reference

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Intra- and inter-molecular C-H...F-C and N-H...F-C hydrogen bonding in secondary amine adducts of B(C6F5)3: relevance to key interactions in alkene polymerisation catalysis

1 reference

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21 January 2018

C-F...H-C hydrogen bonds in ribonucleic acids

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2-Aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies

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Solution and solid-state models of peptide CH...O hydrogen bonds.

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21 January 2018

Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator

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21 January 2018

Design and synthesis of potent and highly selective thrombin inhibitors

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21 January 2018

MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

1 reference

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21 January 2018

Some influences of fluorine in bioorganic chemistry

1 reference

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21 January 2018

Comparison of the molecular structures of six corticosteroids

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21 January 2018

Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes

1 reference

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21 January 2018

Thermodynamic analysis of binding of p-substituted benzamidines to trypsin

1 reference

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21 January 2018

Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors

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21 January 2018

Can the calculation of ligand binding free energies be improved with continuum solvent electrostatics and an ideal-gas entropy correction?

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21 January 2018

Discovery of an orally active series of isoxazoline glycoprotein IIb/IIIa antagonists

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21 January 2018

Models of F.H contacts relevant to the binding of fluoroaromatic inhibitors to carbonic anhydrase II

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21 January 2018

Is fluoride bonded to two Pd acceptors still basic? Three CH2Cl2 molecules encapsulating a Pd2(mu-F)2 square and new implications for catalysis

1 reference

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21 January 2018

A novel intramolecular through-space interaction between F and CN: a strategy for the conformational control of an acyclic system

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21 January 2018

A Demonstration of the Primary Stereoelectronic Effect in the Baeyer-Villiger Oxidation of alpha-Fluorocyclohexanones The Natural Sciences and Engineering Research Council of Canada (NSERC) is gratefully acknowledged for support of this research in

1 reference

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21 January 2018

Cleft-Type Diamidinium Receptors for Dicarboxylate Binding in Protic Solvents

1 reference

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21 January 2018

Molecular Recognition of Amidines in Water

1 reference

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Identifiers

10.1039/B402515F

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

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