(Q44859455)

6 December 2017

title

Dynamic range of Nef functions in chronic HIV-1 infection (English)

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6 December 2017

9

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6 December 2017

11

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6 December 2017

Zabrina L Brumme

10

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Bruce D. Walker

8

object named as

Bruce D Walker

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6 December 2017

Philip Mwimanzi

1

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6 December 2017

Tristan J Markle

2

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6 December 2017

Yoko Ogata

3

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6 December 2017

Eric Martin

4

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6 December 2017

Michiyo Tokunaga

5

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6 December 2017

Macdonald Mahiti

6

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6 December 2017

Xiaomei T Kuang

7

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6 December 2017

language of work or name

English

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publication date

13 March 2013

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6 December 2017

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6 December 2017

volume

439

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6 December 2017

issue

2

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6 December 2017

page(s)

74-80

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CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable

6 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

7 January 2021

1 reference

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Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

7 January 2021

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Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection

7 January 2021

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Genetic characterization of HIV type 1 Nef-induced vesicle secretion

7 January 2021

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Defective nef alleles in a cohort of hemophiliacs with progressing and nonprogressing HIV-1 infection

7 January 2021

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Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection

7 January 2021

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Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS

7 January 2021

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CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression

7 January 2021

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Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

7 January 2021

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Genetic and functional analysis of HIV type 1 nef gene derived from long-term nonprogressor children: association of attenuated variants with slow progression to pediatric AIDS.

7 January 2021

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Nef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation

7 January 2021

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A novel motif in HIV-1 Nef that regulates MIP-1beta chemokine release in macrophages

7 January 2021

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

7 January 2021

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Functional characterization of HIV-1 Nef mutants in the context of viral infection

7 January 2021

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Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates

7 January 2021

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

7 January 2021

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Structure--function relationships in HIV-1 Nef.

7 January 2021

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HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects

7 January 2021

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CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

7 January 2021

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

7 January 2021

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Role of Nef in primate lentiviral immunopathogenesis

7 January 2021

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Functional adaptation of Nef to the immune milieu of HIV-1 infection in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Attenuation of multiple Nef functions in HIV-1 elite controllers

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Nef from a primary isolate of human immunodeficiency virus type 1 lacking the EE(155) region shows decreased ability to down-regulate CD4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

CD4 downregulation by the human immunodeficiency virus type 1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

The nef gene from a long-term HIV type 1 nonprogressor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Statistical significance for genomewide studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

HIV-1 Nef impairs MHC class II antigen presentation and surface expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

HIV-1 glycoprotein 41 ectodomain induces activation of the CD74 protein-mediated extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to enhance viral infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2013.02.005

10.1016/J.VIROL.2013.02.005

7 January 2021

Identifiers

DOI

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6 December 2017

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