(Q44859691)

6 December 2017

Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1. (English)

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Human T-lymphotropic virus 1

6 December 2017

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Hyeon Ung Park

1

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6 December 2017

Jae-Hoon Jeong

series ordinal

2

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6 December 2017

Jay H Chung

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3

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6 December 2017

John N Brady

series ordinal

4

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6 December 2017

language of work or name

English

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publication date

1 June 2004

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6 December 2017

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6 December 2017

23

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6 December 2017

4966-4974

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6 December 2017

29

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207644

6 December 2017

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Molecular biology and pathogenesis of the human T-cell leukaemia/lymphotropic virus Type-1 (HTLV-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: role of tax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Regulation of gene expression by HTLV-I Tax protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Molecular mechanism of tumorigenesis in mice transgenic for the human T cell leukemia virus Tax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

The HTLV-1 tax oncoprotein attenuates DNA damage induced G1 arrest and enhances apoptosis in p53 null cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Mechanisms of G2 arrest in response to overexpression of p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Cell-cycle checkpoint kinases: checking in on the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Structural basis for Chk1 inhibition by UCN-01

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207644

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207644

1 reference

6 December 2017

1 reference