(Q44924216)

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The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain

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Europe PubMed Central

7 December 2017

The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain (English)

1 reference

Europe PubMed Central

7 December 2017

5

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Gary W Brudvig

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Europe PubMed Central

7 December 2017

author name string

David W Konas

1

1 reference

Europe PubMed Central

7 December 2017

Keng Zhu

2

1 reference

Europe PubMed Central

7 December 2017

Manisha Sharma

3

1 reference

Europe PubMed Central

7 December 2017

Kulwant S Aulak

4

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Europe PubMed Central

7 December 2017

Dennis J Stuehr

6

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Europe PubMed Central

7 December 2017

language of work or name

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publication date

4 June 2004

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Europe PubMed Central

7 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

7 December 2017

279

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Europe PubMed Central

7 December 2017

35412-35425

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Europe PubMed Central

7 December 2017

34

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Europe PubMed Central

7 December 2017

Mammalian nitric oxide synthases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide.

1 reference

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21 January 2018

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1 reference

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21 January 2018

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes

1 reference

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21 January 2018

Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation

1 reference

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21 January 2018

Cloning and characterization of a novel human dual flavin reductase

1 reference

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21 January 2018

Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

The Binding of Riboflavin-5′-Phosphate in a Flavoprotein: Flavodoxin at 2.0-Å Resolution

1 reference

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21 January 2018

Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family

1 reference

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21 January 2018

Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

1 reference

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21 January 2018

Tetrahydrobiopterin radical enzymology

1 reference

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21 January 2018

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer

1 reference

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21 January 2018

Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.

1 reference

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21 January 2018

Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III.

1 reference

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21 January 2018

Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains

1 reference

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21 January 2018

Determination of the redox properties of human NADPH-cytochrome P450 reductase

1 reference

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21 January 2018

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

1 reference

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21 January 2018

Electron transfer in human cytochrome P450 reductase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues

1 reference

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21 January 2018

Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself

1 reference

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21 January 2018

Calmodulin activates electron transfer through neuronal nitric-oxide synthase reductase domain by releasing an NADPH-dependent conformational lock

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Electron transfer is activated by calmodulin in the flavin domain of human neuronal nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Removal of a putative inhibitory element reduces the calcium-dependent calmodulin activation of neuronal nitric-oxide synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

The autoinhibitory control element and calmodulin conspire to provide physiological modulation of endothelial and neuronal nitric oxide synthase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Disabling a C-terminal autoinhibitory control element in endothelial nitric-oxide synthase by phosphorylation provides a molecular explanation for activation of vascular NO synthesis by diverse physiological stimuli.

1 reference

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21 January 2018

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

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21 January 2018

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

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21 January 2018

Regulation of neuronal nitric-oxide synthase by calmodulin kinases

1 reference

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21 January 2018

Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

A productive NADP+ binding mode of ferredoxin-NADP + reductase revealed by protein engineering and crystallographic studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400872200

21 January 2018

NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer

1 reference

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21 January 2018

A novel spectroscopic titration method for determining the dissociation constant and stoichiometry of protein-ligand complex

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Location and magnetic relaxation properties of the stable tyrosine radical in photosystem II.

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Electron spin relaxation of iron-sulphur proteins studied by microwave power saturation

1 reference

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21 January 2018

Potentiometric analysis of the flavin cofactors of neuronal nitric oxide synthase

1 reference

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21 January 2018

Engineering of a functional human NADH-dependent cytochrome P450 system

1 reference

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21 January 2018

Electron transfer in flavocytochrome P450 BM3: kinetics of flavin reduction and oxidation, the role of cysteine 999, and relationships with mammalian cytochrome P450 reductase

1 reference

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21 January 2018

Structure of a cytochrome P450-redox partner electron-transfer complex

1 reference

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21 January 2018

Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module

1 reference

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21 January 2018

The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin

1 reference

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21 January 2018

The C terminus of mouse macrophage inducible nitric-oxide synthase attenuates electron flow through the flavin domain

1 reference

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21 January 2018

Competition between C-terminal Tyrosine and Nicotinamide Modulates Pyridine Nucleotide Affinity and Specificity in Plant Ferredoxin-NADP+Reductase

1 reference

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21 January 2018

Trp-676 Facilitates Nicotinamide Coenzyme Exchange in the Reductive Half-Reaction of Human Cytochrome P450 Reductase: Properties of the Soluble W676H and W676A Mutant Reductases†

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M400872200

1 reference

Europe PubMed Central

7 December 2017

release_h7nichho3bbetay4bxmkg32t24

1 reference

https://api.fatcat.wiki/v0/release/h7nichho3bbetay4bxmkg32t24

24 November 2022

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mapped directly with Wikidata item

1 reference

Europe PubMed Central

7 December 2017

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