(Q44995245)

8 December 2017

title

Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions (English)

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8 December 2017

D F V Lewis

1

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8 December 2017

B G Lake

series ordinal

2

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8 December 2017

M Dickins

series ordinal

3

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8 December 2017

P S Goldfarb

series ordinal

4

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8 December 2017

language of work or name

English

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publication date

1 June 2004

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8 December 2017

number of pages

21

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based on heuristic

inferred from page(s)

published in

Xenobiotica

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8 December 2017

volume

34

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8 December 2017

issue

6

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8 December 2017

page(s)

549-569

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Molecular mechanics calculations of proteins. Comparison of different energy minimization strategies.

8 December 2017

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Solvent-accessible surfaces of proteins and nucleic acids

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Pharmacophore modeling of cytochromes P450.

21 January 2018

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Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

21 January 2018

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Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.

21 January 2018

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

21 January 2018

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Cytochrome P-450 3A4: regulation and role in drug metabolism

21 January 2018

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Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

21 January 2018

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Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

21 January 2018

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Allosteric phenomena in cytochrome P450-catalyzed monooxygenations

21 January 2018

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CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

21 January 2018

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Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes

21 January 2018

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Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4.

21 January 2018

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Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation

21 January 2018

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Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations

21 January 2018

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Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure

21 January 2018

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On the Estimation of Binding Affinity (&#916;Gbind) for Human P450 Substrates (Based on Km and K&#916; Values)

21 January 2018

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Substrates of human hepatic cytochrome P450 3A4.

21 January 2018

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Summary of information on human CYP enzymes: human P450 metabolism data

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21 January 2018

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CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

21 January 2018

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Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

21 January 2018

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In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

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Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

21 January 2018

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Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

21 January 2018

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

21 January 2018

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The human CYP3A subfamily: practical considerations

21 January 2018

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Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation.

21 January 2018

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Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

21 January 2018

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10.1080/00498250410001691325

21 January 2018

Identifiers

DOI

1 reference

8 December 2017

1 reference