(Q45069664)

9 December 2017

title

"Chemical analogues" of HLA-DM can induce a peptide-receptive state in HLA-DR molecules (English)

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9 December 2017

3

Olaf Rötzschke

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9 December 2017

author name string

Viviana Marin-Esteban

series ordinal

1

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9 December 2017

Kirsten Falk

series ordinal

2

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9 December 2017

language of work or name

English

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publication date

20 September 2004

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Journal of Biological Chemistry

9 December 2017

published in

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9 December 2017

volume

279

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9 December 2017

issue

49

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9 December 2017

page(s)

50684-50690

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Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

9 December 2017

cites work

1 reference

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Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding

21 January 2018

1 reference

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The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation

21 January 2018

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Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM

21 January 2018

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21 January 2018

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Mediation by HLA-DM of dissociation of peptides from HLA-DR

21 January 2018

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The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide

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Formation of a highly peptide-receptive state of class II MHC.

21 January 2018

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HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules

21 January 2018

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HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH

21 January 2018

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Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules

21 January 2018

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Small-molecular compounds enhance the loading of APC with encephalitogenic MBP protein.

21 January 2018

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HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

21 January 2018

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Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein

21 January 2018

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Induction and suppression of an autoimmune disease by oligomerized T cell epitopes: enhanced in vivo potency of encephalitogenic peptides

21 January 2018

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Peptide binding to active class II MHC protein on the cell surface

21 January 2018

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MHC class II function preserved by low-affinity peptide interactions preceding stable binding

21 January 2018

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The kinetic basis of peptide exchange catalysis by HLA-DM

21 January 2018

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Determination of the HLA-DM interaction site on HLA-DR molecules

21 January 2018

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Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides

21 January 2018

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Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis

21 January 2018

1 reference

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A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules

21 January 2018

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T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

21 January 2018

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Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M407598200

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9 December 2017

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