(Q45174128)

10 December 2017

title

Antibody diversity: one enzyme to rule them all. (English)

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10 December 2017

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Michel C. Nussenzweig

series ordinal

1

object named as

Michel C Nussenzweig

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10 December 2017

Frederick W Alt

2

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10 December 2017

language of work or name

English

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publication date

1 December 2004

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10 December 2017

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10 December 2017

volume

10

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10 December 2017

issue

12

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10 December 2017

page(s)

1304-1305

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The generation of antibody diversity through somatic hypermutation and class switch recombination

10 December 2017

cites work

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https://api.crossref.org/works/10.1038%2FNM1204-1304

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Transcription-coupled events associating with immunoglobulin switch region chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

H2AX: the histone guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

The cellular response to general and programmed DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Constitutive expression of AID leads to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1204-1304

21 January 2018

Identifiers

DOI

10.1038/NM1204-1304

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Dimensions Publication ID

10 December 2017

1001881981

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1 reference