(Q45111031)

9 December 2017

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. (English)

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9 December 2017

Shyam Unniraman

1

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9 December 2017

Shaoming Zhou

series ordinal

2

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9 December 2017

David G Schatz

series ordinal

3

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9 December 2017

language of work or name

English

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publication date

17 October 2004

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9 December 2017

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9 December 2017

5

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9 December 2017

1117-1123

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9 December 2017

11

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Mechanisms of chromosomal translocations in B cell lymphomas

9 December 2017

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Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system

21 January 2018

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Chromosome translocations in multiple myeloma

21 January 2018

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The role of DNA breaks in genomic instability and tumorigenesis

21 January 2018

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Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

21 January 2018

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Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

21 January 2018

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Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

21 January 2018

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Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

21 January 2018

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The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

21 January 2018

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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Immunoglobulin switch recombination may occur by a DNA end-joining mechanism.

21 January 2018

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

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The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region

21 January 2018

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Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination

21 January 2018

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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AID: how does it aid antibody diversity?

21 January 2018

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The generation of antibody diversity through somatic hypermutation and class switch recombination

21 January 2018

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Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations

21 January 2018

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Neoplastic development in plasma cells

21 January 2018

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Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2.

21 January 2018

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Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction

21 January 2018

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Chromosomal translocations deregulating c-myc are associated with normal immune responses.

21 January 2018

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AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

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Experimental plasmacytomagenesis in mice

21 January 2018

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DNA double strand break repair and chromosomal translocation: lessons from animal models

21 January 2018

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Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes.

21 January 2018

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Immunoglobulin class switching

21 January 2018

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Transcription-coupled events associating with immunoglobulin switch region chromatin

21 January 2018

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

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R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

21 January 2018

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A human nuclease specific for G4 DNA

21 January 2018

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Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA

21 January 2018

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Internal IgH class switch region deletions are position-independent and enhanced by AID expression

21 January 2018

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The role of c-myc in cell growth

21 January 2018

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Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

21 January 2018

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

21 January 2018

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DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

21 January 2018

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The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

21 January 2018

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AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation

21 January 2018

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

21 January 2018

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Genome-wide somatic hypermutation

21 January 2018

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Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

21 January 2018

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Constitutive expression of AID leads to tumorigenesis

21 January 2018

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

21 January 2018

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The influence of transcriptional orientation on endogenous switch region function

21 January 2018

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7 January 2021

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

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7 January 2021

A matter of life and cell death

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7 January 2021

Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA

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7 January 2021

Identifiers

DOI

10.1038/NI1127

1 reference

release_ffvduypyz5euredvlhryaugmu4

9 December 2017

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Fatcat

https://api.fatcat.wiki/v0/release/ffvduypyz5euredvlhryaugmu4

24 November 2022

mapped directly with Wikidata item

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