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AID: how does it aid antibody diversity?

scientific article published on June 2004

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Europe PubMed Central

10 August 2017

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Europe PubMed Central

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AID: how does it aid antibody diversity? (English)

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stated in

Europe PubMed Central

10 August 2017

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1

Tasuku Honjo

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Europe PubMed Central

10 August 2017

2

Masamichi Muramatsu

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Europe PubMed Central

10 August 2017

3

Sidonia Fagarasan

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Europe PubMed Central

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15189732

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10 August 2017

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English

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1 June 2004

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Europe PubMed Central

10 August 2017

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Europe PubMed Central

10 August 2017

20

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Europe PubMed Central

10 August 2017

6

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stated in

Europe PubMed Central

10 August 2017

659-668

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stated in

Europe PubMed Central

10 August 2017

Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Unmutated immunoglobulin M can protect mice from death by influenza virus infection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Uracil in DNA--occurrence, consequences and repair

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Somatic hypermutation of the AID transgene in B and non-B cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Non-redundancy of cytidine deaminases in class switch recombination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Constitutive expression of AID leads to tumorigenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The AID enzyme induces class switch recombination in fibroblasts

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID mediates hypermutation by deaminating single stranded DNA.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Human genetic defects in class-switch recombination (hyper-IgM syndromes).

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Molecular cloning of an apolipoprotein B messenger RNA editing protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Genomic instability in mice lacking histone H2AX

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

What role for AID: mutator, or assembler of the immunoglobulin mutasome?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Intestinal IgA synthesis: regulation of front-line body defences

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Lessons learned from structural results on uracil-DNA glycosylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Specific binding of human MSH2.MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

DNA-dependent protein kinase activity is not required for immunoglobulin class switching

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Ku80 is required for immunoglobulin isotype switching

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Vaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity: catalytic site mutations reduce virulence but not virus replication in cultured cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID and mismatch repair in antibody diversification

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

AID mutant analyses indicate requirement for class-switch-specific cofactors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

The V(D)J recombination activating gene, RAG-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.IMMUNI.2004.05.011

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10.1016/J.IMMUNI.2004.05.011

1 reference

stated in

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

PubMed ID

15189732

retrieved

10 August 2017

ResearchGate publication ID

8517060

0 references

(Q35800376)

AID: how does it aid antibody diversity?

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