(Q34770418)

4 August 2017

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title

AID and mismatch repair in antibody diversification (English)

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4 August 2017

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2

Matthew D Scharff

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4 August 2017

Alberto Martin

1

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4 August 2017

publication date

1 August 2002

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Nature Reviews Immunology

4 August 2017

published in

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4 August 2017

volume

2

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4 August 2017

issue

8

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4 August 2017

page(s)

605-614

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https://scigraph.springernature.com/pub.10.1038/nri858

4 August 2017

exact match

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cites work

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The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription.

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Somatic hypermutation: how many mechanisms diversify V region sequences?

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Increased transcription levels induce higher mutation rates in a hypermutating cell line

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Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

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The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

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Somatic hypermutation in the heavy chain locus correlates with transcription

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

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The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.

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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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The AID enzyme induces class switch recombination in fibroblasts

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Molecular mechanism of class switch recombination: linkage with somatic hypermutation

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Mechanisms of chromosomal translocations in B cell lymphomas

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

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The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks

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DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

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The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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Mouse models for human DNA mismatch-repair gene defects

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Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

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Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

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Mismatch repair and immunoglobulin gene hypermutation: did we learn something?

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Severe attenuation of the B cell immune response in Msh2-deficient mice

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Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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Emerging links between hypermutation of antibody genes and DNA polymerases

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Error-prone candidates vie for somatic mutation

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Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation

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The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

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Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

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A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

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Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells

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The mechanism of mammalian gene replacement is consistent with the formation of long regions of heteroduplex DNA associated with two crossing-over events

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Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

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Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

21 January 2018

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

21 January 2018

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Quantitative regulation of class switch recombination by switch region transcription

21 January 2018

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Processing of switch transcripts is required for targeting of antibody class switch recombination

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

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Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination

21 January 2018

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Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch

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Ku80 is required for immunoglobulin isotype switching

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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

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Immunoglobulin switch recombination may occur by a DNA end-joining mechanism.

21 January 2018

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Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

21 January 2018

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Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

21 January 2018

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Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

21 January 2018

1 reference

Linking class-switch recombination with somatic hypermutation

21 January 2018

1 reference

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

21 January 2018

1 reference

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

1 reference

Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1

21 January 2018

1 reference

APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

21 January 2018

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RNA editing by base deamination: more enzymes, more targets, new mysteries

21 January 2018

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Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.

21 January 2018

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Specific binding of human MSH2.MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases.

21 January 2018

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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

21 January 2018

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Recent progress in the biology, chemistry and structural biology of DNA glycosylases

21 January 2018

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Structure and function in the uracil-DNA glycosylase superfamily

21 January 2018

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Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts

21 January 2018

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21 January 2018

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DNA mismatch repair and genetic instability

21 January 2018

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Mismatch repair in replication fidelity, genetic recombination, and cancer biology

21 January 2018

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Somatic hypermutation of immunoglobulin and non-immunoglobulin genes

21 January 2018

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Mismatch repair co-opted by hypermutation.

21 January 2018

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Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

21 January 2018

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Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase

21 January 2018

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Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

21 January 2018

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Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

21 January 2018

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Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching

21 January 2018

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Altered spectra of hypermutation in DNA repair-deficient mice

21 January 2018

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Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

1 reference

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

21 January 2018

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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

21 January 2018

1 reference

Progress in understanding the mechanism and consequences of somatic hypermutation

31 March 2020

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Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

31 March 2020

1 reference

The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression

31 March 2020

1 reference

The PU.1 and NF-EM5 binding motifs in the Igkappa 3' enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vkappa gene

31 March 2020

1 reference

Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation

31 March 2020

1 reference

Strand breaks in immunoglobulin gene hypermutation

31 March 2020

1 reference

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

31 March 2020

1 reference

Light chain gene conversion continues at high rate in an ALV-induced cell line.

31 March 2020

1 reference

Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination

31 March 2020

1 reference

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

31 March 2020

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Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation

31 March 2020

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Dimensions Publication ID

31 March 2020

Identifiers

DOI

10.1038/NRI858

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1041294141

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