(Q34297090)

1 August 2017

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title

Linking class-switch recombination with somatic hypermutation (English)

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1 August 2017

K Kinoshita

1

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1 August 2017

T Honjo

series ordinal

2

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1 August 2017

publication date

1 July 2001

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Nature Reviews Molecular Cell Biology

1 August 2017

published in

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1 August 2017

volume

2

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1 August 2017

issue

7

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1 August 2017

page(s)

493-503

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Initial sequencing and analysis of the human genome

1 August 2017

cites work

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The Sequence of the Human Genome

21 January 2018

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V(D)J recombination: on the cutting edge

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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Organization of immunoglobulin heavy chain genes and allelic deletion model

21 January 2018

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Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch

21 January 2018

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Exon shuffling generates an immunoglobulin heavy chain gene

21 January 2018

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Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression

21 January 2018

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Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

21 January 2018

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DNA sequences mediating class switching in alpha-immunoglobulins

21 January 2018

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Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

21 January 2018

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Circular DNA is excised by immunoglobulin class switch recombination

21 January 2018

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Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching

21 January 2018

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Circular DNA is a product of the immunoglobulin class switch rearrangement

21 January 2018

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

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The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

21 January 2018

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Ku80 is required for immunoglobulin isotype switching

21 January 2018

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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

21 January 2018

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Shutdown of class switch recombination by deletion of a switch region control element.

21 January 2018

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An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.

21 January 2018

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Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences

21 January 2018

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Extrachromosomal eukaryotic DNA substrates for switch recombination: analysis of isotype and cell specificity

21 January 2018

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Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences

21 January 2018

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Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions

21 January 2018

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Sensitive analysis of recombination activity using integrated cell surface reporter substrates

21 January 2018

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High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.

21 January 2018

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The mu switch region tandem repeats are important, but not required, for antibody class switch recombination

21 January 2018

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Palindromic but not G-rich sequences are targets of class switch recombination

21 January 2018

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Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals

21 January 2018

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A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics

21 January 2018

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Frequent but biased class switch recombination in the S mu flanking regions.

21 January 2018

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DNA sequences at immunoglobulin switch region recombination sites

21 January 2018

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Towards an understanding of somatic hypermutation

21 January 2018

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Somatic hypermutation of an immunoglobulin mu heavy chain transgene

21 January 2018

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Somatic hypermutation in the heavy chain locus correlates with transcription

21 January 2018

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Increased transcription levels induce higher mutation rates in a hypermutating cell line

21 January 2018

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

21 January 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

21 January 2018

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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

21 January 2018

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

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A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript

21 January 2018

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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

21 January 2018

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Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

21 January 2018

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TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

21 January 2018

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

21 January 2018

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Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

21 January 2018

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B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes

21 January 2018

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Mismatch repair co-opted by hypermutation.

21 January 2018

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Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

21 January 2018

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Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

21 January 2018

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

21 January 2018

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Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

21 January 2018

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Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

21 January 2018

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Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

21 January 2018

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Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

21 January 2018

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A hyperconversion mechanism generates the chicken light chain preimmune repertoire

21 January 2018

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Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

21 January 2018

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Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

1 reference

RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA

21 January 2018

1 reference

Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.

21 January 2018

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RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination

21 January 2018

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Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells

21 January 2018

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Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis

21 January 2018

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Molecular cloning of an apolipoprotein B messenger RNA editing protein

21 January 2018

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A mammalian RNA editing enzyme

21 January 2018

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Regulation of alternative splicing by RNA editing

21 January 2018

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Regulation of serotonin-2C receptor G-protein coupling by RNA editing

21 January 2018

1 reference

Two naturally occurring alpha2,6-sialyltransferase forms with a single amino acid change in the catalytic domain differ in their catalytic activity and proteolytic processing

21 January 2018

1 reference

Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing

21 January 2018

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GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases

21 January 2018

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RNA editing in the Wilms' tumor susceptibility gene, WT1

21 January 2018

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Pecularities of immunoglobulin gene structures as a basis for somatic mutation emergence

21 January 2018

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The role of gene deletion in the immunoglobulin heavy chain switch

21 January 2018

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CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

21 January 2018

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An immunoglobulin heavy-chain gene is formed by at least two recombinational events

21 January 2018

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Recombination between immunoglobulin variable region gene segments is enhanced by transcription

21 January 2018

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Origin of Antibody Variation

21 January 2018

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Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

21 January 2018

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Complex layers of genetic alteration in the generation of antibody diversity

21 January 2018

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7 January 2021

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

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7 January 2021

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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7 January 2021

Molecular requirements for immunoglobulin heavy chain constant region gene switch-recombination revealed with switch-substrate retroviruses

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7 January 2021

Progress in understanding the mechanism and consequences of somatic hypermutation

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7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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7 January 2021

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

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7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

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7 January 2021

Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process

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7 January 2021

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

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7 January 2021

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

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7 January 2021

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

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7 January 2021

Normal CD40-mediated activation of monocytes and dendritic cells from patients with hyper-IgM syndrome due to a CD40 pathway defect in B cells

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7 January 2021

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

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7 January 2021

Identifiers

DOI

10.1038/35080033

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Dimensions Publication ID

1 August 2017

1021224791

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