(Q55034838)

16 June 2018

title

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. (English)

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16 June 2018

author

Igor B. Rogozin

1

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16 June 2018

author name string

Pavlov YI

2

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16 June 2018

Bebenek K

3

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16 June 2018

Matsuda T

4

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16 June 2018

Kunkel TA

5

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16 June 2018

language of work or name

English

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publication date

1 June 2001

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16 June 2018

published in

Nature Immunology

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16 June 2018

volume

2

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16 June 2018

issue

6

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16 June 2018

page(s)

530-536

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16 June 2018

cites work

Somatic hypermutation

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7 January 2021

Towards an understanding of somatic hypermutation

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7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

7 January 2021

Mutation drift and repertoire shift in the maturation of the immune response

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7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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7 January 2021

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

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7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. III. Somatic mutations in the chicken light chain locus

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7 January 2021

Mutation, selection, and memory in B lymphocytes of exothermic vertebrates

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7 January 2021

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

1 reference

7 January 2021

Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

1 reference

7 January 2021

Critical test of hot spot motifs for immunoglobulin hypermutation

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7 January 2021

Clonal selection and learning in the antibody system

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7 January 2021

Codon bias targets mutation.

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7 January 2021

Both DNA strands of antibody genes are hypermutation targets

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7 January 2021

Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs

1 reference

7 January 2021

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

1 reference

7 January 2021

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

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7 January 2021

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

1 reference

7 January 2021

Somatic diversification of chicken immunoglobulin light chains by point mutations

1 reference

7 January 2021

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

1 reference

7 January 2021

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron

1 reference

7 January 2021

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

1 reference

7 January 2021

A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript

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7 January 2021

Analysis of somatic mutations in kappa transgenes

1 reference

7 January 2021

Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome

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7 January 2021

The subclass approach for mutational spectrum analysis: application of the SEM algorithm.

1 reference

7 January 2021

Origin of Antibody Variation

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7 January 2021

The role of DNA repair in somatic hypermutation of immunoglobulin genes

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7 January 2021

Somatic hypermutation and the three R's: repair, replication and recombination

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7 January 2021

Error-prone candidates vie for somatic mutation

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7 January 2021

The expanding polymerase universe

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7 January 2021

Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA.

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7 January 2021

The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance

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7 January 2021

hRAD30 mutations in the variant form of xeroderma pigmentosum

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7 January 2021

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

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7 January 2021

Low fidelity DNA synthesis by human DNA polymerase-eta.

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7 January 2021

Proofreading of DNA polymerase eta-dependent replication errors

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7 January 2021

Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene

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7 January 2021

Pecularities of immunoglobulin gene structures as a basis for somatic mutation emergence

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7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. I. Correlation between somatic mutations and repeats. Somatic mutation properties and clonal selection

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7 January 2021

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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7 January 2021

Use of mutation spectra analysis software.

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7 January 2021

The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation

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7 January 2021

Identifiers

DOI

10.1038/88732

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16 June 2018

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16 June 2018