(Q45189674)

10 December 2017

Cytometric methods to detect apoptosis (English)

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10 December 2017

Cytometric Methods to Detect Apoptosis (English)

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1 reference

Zbyszek Darzynkiewicz

1

object named as

Zbigniew Darzynkiewicz

1 reference

10 December 2017

Xuan Huang

2

1 reference

10 December 2017

Masaki Okafuji

3

1 reference

10 December 2017

Malcolm A King

4

1 reference

10 December 2017

Malcolm A. King

4

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publication date

1 January 2004

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10 December 2017

2004

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published in

Methods in Cell Biology

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10 December 2017

75

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10 December 2017

307-341

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Human ICE/CED-3 protease nomenclature

10 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Analysis of apoptosis by laser scanning cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Cell death beyond apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Biochemical pathways of caspase activation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Analysis of mitochondria during cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Cell death: critical control points

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Acid-induced denaturation of DNA in situ as a probe of chromatin structure

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https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Difficulties and pitfalls in analysis of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Laser-scanning cytometry: A new instrumentation with many applications

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Features of apoptotic cells measured by flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Comparison of methods based on annexin-V binding, DNA content or TUNEL for evaluating cell death in HL-60 and adherent MCF-7 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Chromatin condensation and sensitivity of DNA in situ to denaturation during cell cycle and apoptosis--a confocal microscopy study

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

A new flow cytometric method for discrimination of apoptotic cells and detection of their cell cycle specificity through staining of F-actin and DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

1 reference

7 January 2021

The most unkindest cut of all: on the multiple roles of mammalian caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Induction and activation of tissue transglutaminase during programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

1 reference

7 January 2021

Apoptosis meets signal transduction: elimination of a BAD influence

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection of in situ activation of transglutaminase during apoptosis: correlation with the cell cycle phase by multiparameter flow and laser scanning cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Effect of Protease Inhibitors on Early Events of Apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Flow cytometric detection of apoptosis: Comparison of the assays of in situ DNA degradation and chromatin changes

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Rhodamine 110-Linked Amino Acids and Peptides as Substrates To Measure Caspase Activity upon Apoptosis Induction in Intact Cells†

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Localization of mitochondria in living cells with rhodamine 123

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Development and application of a GFP-FRET intracellular caspase assay for drug screening

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Laser scanning cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Staining of mitochondrial membranes with 10-nonyl acridine orange, MitoFluor Green, and MitoTracker Green is affected by mitochondrial membrane potential altering drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

There is substantial nuclear and cellular disintegration before detectable phosphatidylserine exposure during the camptothecin-induced apoptosis of HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Programmed cell death without DNA fragmentation in the jimpy mouse: secreted factors can enhance survival

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

The mitochondrion as an integrator/coordinator of cell death pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection and characterization, using fluoresceincadaverine, of amine acceptor protein substrates accessible to active transglutaminase expressed by rabbit articular chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

DEVDase detection in intact apoptotic cells using the cell permeant fluorogenic substrate, (z-DEVD)2-cresyl violet

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Four deaths and a funeral: from caspases to alternative mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Cleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

During apoptosis of HL-60 and U-937 cells caspases are activated independently of dissipation of mitochondrial electrochemical potential

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Fluorescent molecular probes V: a sensitive caspase-3 substrate for fluorometric assays

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFalpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

'Tissue' transglutaminase in cell death: a downstream or a multifunctional upstream effector?

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Apoptotic DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

The study of apoptotic cells by flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Discrimination of apoptotic thymocytes by forward light scatter

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Cisplatin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Increased membrane permeability of apoptotic thymocytes: a flow cytometric study.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Mouse testis cell sorting according to DNA and mitochondrial changes during spermatogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection of apoptosis in live cells by MitoTracker red CMXRos and SYTO dye flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Apoptotic human lymphocytes have diminished CD4 and CD8 receptor expression

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Molecular Components of a Cell Death Pathway Activated by Endoplasmic Reticulum Stress

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Nucleolar segregation during apoptosis of haemopoietic stem cell line FDCP-Mix.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

In situ flow cytometric analysis of nonyl acridine orange-stained mitochondria from splenocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Chloromethyltetramethylrosamine (Mitotracker Orange) induces the mitochondrial permeability transition and inhibits respiratory complex I. Implications for the mechanism of cytochrome c release.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Death and decoy receptors and p53-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Mechanisms of caspase activation and inhibition during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Kinetics of HL-60 cell entry to apoptosis during treatment with TNF-alpha or camptothecin assayed by the stathmo-apoptosis method

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection of localized caspase activity in early apoptotic cells by laser scanning cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

In vivo DNA degradation in thymocytes of gamma-irradiated or hydrocortisone-treated rats

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Flow cytometry of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Early events in the anoikis program occur in the absence of caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Detection of programmed cell death using fluorescence energy transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Mitochondrial control of nuclear apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Single-step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides: detection of apoptosis and bromodeoxyuridine incorporation.

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0091-679X%2804%2975012-8

7 January 2021

10.1016/S0091-679X(04)75012-8

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