(Q45221614)

11 December 2017

title

Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting (English)

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11 December 2017

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Annamaria Naggi

1

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11 December 2017

Benito Casu

2

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11 December 2017

Marta Perez

3

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11 December 2017

Giangiacomo Torri

4

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11 December 2017

Giuseppe Cassinelli

5

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11 December 2017

Sergio Penco

6

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11 December 2017

Claudio Pisano

7

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11 December 2017

Giuseppe Giannini

8

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11 December 2017

Rivka Ishai-Michaeli

9

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11 December 2017

Israel Vlodavsky

10

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11 December 2017

language of work or name

English

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publication date

12 January 2005

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Journal of Biological Chemistry

11 December 2017

published in

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11 December 2017

volume

280

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11 December 2017

issue

13

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11 December 2017

page(s)

12103-12113

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Heparanase, a potential regulator of cell-matrix interactions

11 December 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M414217200

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

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Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

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Human heparanase. Purification, characterization, cloning, and expression

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Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells

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Heterodimer formation is essential for heparanase enzymatic activity

21 January 2018

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Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis

21 January 2018

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Increased expression of heparanase in puromycin aminonucleoside nephrosis

21 January 2018

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Functions of cell surface heparan sulfate proteoglycans

21 January 2018

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Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.

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Heparanases and tumor metastasis

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Proteoglycans: structures and interactions

21 January 2018

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Structure and biological interactions of heparin and heparan sulfate

21 January 2018

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'Heparin'--from anticoagulant drug into the new biology

21 January 2018

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Novel drug development opportunities for heparin.

21 January 2018

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2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity

21 January 2018

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Chemically modified heparins as inhibitors of heparan sulfate specific endo-beta-glucuronidase (heparanase) of metastatic melanoma cells

21 January 2018

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A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer

21 January 2018

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Importance of size and sulfation of heparin in release of basic fibroblast growth factor from the vascular endothelium and extracellular matrix

21 January 2018

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Undersulfated and glycol-split heparins endowed with antiangiogenic activity

21 January 2018

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Short heparin sequences spaced by glycol-split uronate residues are antagonists of fibroblast growth factor 2 and angiogenesis inhibitors

21 January 2018

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Substrate specificity of heparanases from human hepatoma and platelets

21 January 2018

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Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence

21 January 2018

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Molecular weight determination of heparin and dermatan sulfate by size exclusion chromatography with a triple detector array

21 January 2018

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Solvolytic desulfation of glycosaminoglycuronan sulfates with dimethyl sulfoxide containing water or methanol

21 January 2018

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Studies on heparin degradation. I. Preparation of ( 35 S) sulphamate derivatives for studies on heparin degrading enzymes of mammalian origin

21 January 2018

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The N-acetylation and estimation of hexosamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

Identification of active-site residues of the pro-metastatic endoglycosidase heparanase

21 January 2018

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Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans

21 January 2018

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Structure of a heparin-linked biologically active dimer of fibroblast growth factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M414217200

Conformation and dynamics of heparin and heparan sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

Undersulfated, low-molecular-weight glycol-split heparin as an antiangiogenic VEGF antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

Heparanase expression in hepatocellular carcinoma and the cirrhotic liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414217200

21 January 2018

Identifiers

DOI

10.1074/JBC.M414217200

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11 December 2017

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