(Q45268625)

English

Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats

scientific article published in January 2005

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scholarly article

1 reference

Europe PubMed Central

11 December 2017

Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats (English)

1 reference

Europe PubMed Central

11 December 2017

author name string

Kuo-Sheng Hung

1

1 reference

Europe PubMed Central

11 December 2017

Shiuh-Lin Hwang

2

1 reference

Europe PubMed Central

11 December 2017

Chung-Ling Liang

3

1 reference

Europe PubMed Central

11 December 2017

Yann-Jang Chen

4

1 reference

Europe PubMed Central

11 December 2017

Tsung-Hsing Lee

5

1 reference

Europe PubMed Central

11 December 2017

Jong-Kang Liu

6

1 reference

Europe PubMed Central

11 December 2017

Shen-Long Howng

7

1 reference

Europe PubMed Central

11 December 2017

Cheng-Haung Wang

8

1 reference

Europe PubMed Central

11 December 2017

publication date

1 January 2005

1 reference

Europe PubMed Central

11 December 2017

Journal of Neuropathology & Experimental Neurology

1 reference

Europe PubMed Central

11 December 2017

64

1 reference

Europe PubMed Central

11 December 2017

1

1 reference

Europe PubMed Central

11 December 2017

15-26

1 reference

Europe PubMed Central

11 December 2017

Targeting the host inflammatory response in traumatic spinal cord injury

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Repair of chronic spinal cord injury

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Regeneration of cut adult axons fails even in the presence of continuous aligned glial pathways.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

The CNS lesion scar: new vistas on an old regeneration barrier

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Tumor necrosis factor-alpha regulation of the Id gene family in astrocytes and microglia during CNS inflammatory injury.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Mechanism of myelin breakdown in experimental demyelination: a putative role for calpain

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Cell death and plasticity after experimental spinal cord injury

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Inhibition of calpain-mediated apoptosis by E-64 d-reduced immediate early gene (IEG) expression and reactive astrogliosis in the lesion and penumbra following spinal cord injury in rats

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

The calpain system

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Calpain and its involvement in the pathophysiology of CNS injuries and diseases: therapeutic potential of calpain inhibitors for prevention of neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Protective effect of MDL28170 against thioacetamide-induced acute liver failure in mice

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

A sensitive and reliable locomotor rating scale for open field testing in rats

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death Struggle in the Penumbra

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Involvement of cellular proteolytic machinery in apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Glutamate Neurotoxicity Is Independent of Calpain I Inhibition in Primary Cultures of Cerebellar Granule Cells

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Hypoperfusion and vasoreactivity in the thalamus and cerebellum after stroke.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Inhibition of Bax channel-forming activity by Bcl-2

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells.

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Pretreatment with Calpain Inhibitor CEP-4143 Inhibits Calpain I Activation and Cytoskeletal Degradation, Improves Neurological Function, and Enhances Axonal Survival After Traumatic Spinal Cord Injury

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.1.15

21 January 2018

Identifiers

10.1093/JNEN/64.1.15

1 reference

Europe PubMed Central

11 December 2017

1 reference

Europe PubMed Central

11 December 2017

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