(Q45269798)

11 December 2017

title

Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis (English)

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11 December 2017

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Onikepe Adegbola

1

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11 December 2017

Gary R Pasternack

series ordinal

2

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11 December 2017

language of work or name

English

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publication date

16 February 2005

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Journal of Biological Chemistry

11 December 2017

published in

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11 December 2017

volume

280

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11 December 2017

issue

16

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11 December 2017

page(s)

15497-15502

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The Rb/E2F pathway and cancer

11 December 2017

cites work

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Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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Effects of an Rb mutation in the mouse

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

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Rb function in cell-cycle regulation and apoptosis

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Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb.

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Constitutively active protein phosphatase 1alpha causes Rb-dependent G1 arrest in human cancer cells

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Protein phosphatase 1alpha-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma protein

21 January 2018

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The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis

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Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis

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Retinoblastoma protein is frequently absent or phosphorylated in anaplastic large-cell lymphoma

21 January 2018

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Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb.

21 January 2018

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Coordinated regulation of life and death by RB.

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A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons.

21 January 2018

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

21 January 2018

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Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

21 January 2018

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Identification of sequences required for inhibition of oncogene-mediated transformation by pp32.

21 January 2018

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Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci

21 January 2018

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Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A.

21 January 2018

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Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein

21 January 2018

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Tumor suppression and potentiation by manipulation of pp32 expression

21 January 2018

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pp32 reduction induces differentiation of TSU-Pr1 cells

21 January 2018

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Novel nuclear phosphoprotein pp32 is highly expressed in intermediate- and high-grade prostate cancer

21 January 2018

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Ribosome-binding protein p34 is a member of the leucine-rich-repeat-protein superfamily

21 January 2018

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Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites

21 January 2018

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Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

21 January 2018

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Modulation of oncogenic potential by alternative gene use in human prostate cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M411382200

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11 December 2017

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