(Q35058588)

6 August 2017

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title

Coordinated regulation of life and death by RB. (English)

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6 August 2017

B Nelson Chau

1

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6 August 2017

Jean Y J Wang

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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6 August 2017

Nature Reviews Cancer

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6 August 2017

3

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6 August 2017

2

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6 August 2017

130-138

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https://scigraph.springernature.com/pub.10.1038/nrc993

6 August 2017

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cites work

The Rb/E2F pathway and cancer

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Rb function in cell-cycle regulation and apoptosis

21 January 2018

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Rb targets histone H3 methylation and HP1 to promoters

21 January 2018

1 reference

Requirement for a functional Rb-1 gene in murine development

21 January 2018

1 reference

Effects of an Rb mutation in the mouse

21 January 2018

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

1 reference

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

1 reference

Apaf-1 is a transcriptional target for E2F and p53

21 January 2018

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APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

21 January 2018

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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

21 January 2018

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Direct coupling of the cell cycle and cell death machinery by E2F.

21 January 2018

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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

21 January 2018

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E2F1 and p53 are dispensable, whereas p21(Waf1/Cip1) cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis

21 January 2018

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The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein

21 January 2018

1 reference

pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.

21 January 2018

1 reference

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

21 January 2018

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Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

21 January 2018

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

21 January 2018

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Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb.

21 January 2018

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The caspase-RB connection in cell death

21 January 2018

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Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis

21 January 2018

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Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death.

21 January 2018

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Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis.

21 January 2018

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Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

21 January 2018

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Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis

21 January 2018

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Retinoblastoma protein partners

21 January 2018

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Regulation of cell death by the Abl tyrosine kinase

21 January 2018

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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

21 January 2018

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Rb protein down-regulates the stress-activated signals through inhibiting c-Jun N-terminal kinase/stress-activated protein kinase.

21 January 2018

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Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein

21 January 2018

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Control of apoptosis by Rel/NF-kappaB transcription factors

21 January 2018

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Cellular survival: a play in three Akts

21 January 2018

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21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

21 January 2018

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5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

21 January 2018

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Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

21 January 2018

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Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

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Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

21 January 2018

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

21 January 2018

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Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma

21 January 2018

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Minimal regions of chromosomal imbalance in retinoblastoma detected by comparative genomic hybridization

21 January 2018

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Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

21 January 2018

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Myc requires distinct E2F activities to induce S phase and apoptosis

31 March 2020

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Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice

31 March 2020

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Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

31 March 2020

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E2F-1 functions in mice to promote apoptosis and suppress proliferation

31 March 2020

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The large subunit of replication factor C promotes cell survival after DNA damage in an LxCxE motif- and Rb-dependent manner

31 March 2020

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Detection of chromosome imbalances in retinoblastoma by parallel karyotype and CGH analyses

31 March 2020

1 reference

Cooperative tumorigenic effects of germline mutations in Rb and p53

31 March 2020

1 reference

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC993

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Dimensions Publication ID

6 August 2017

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