(Q45271574)

11 December 2017

title

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains (English)

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11 December 2017

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Ellen W Doss-Pepe

1

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11 December 2017

Li Chen

series ordinal

2

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11 December 2017

Kiran Madura

series ordinal

3

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11 December 2017

language of work or name

English

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publication date

16 February 2005

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Journal of Biological Chemistry

11 December 2017

published in

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11 December 2017

volume

280

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11 December 2017

issue

17

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11 December 2017

page(s)

16619-16624

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The ubiquitin pathway for protein degradation

11 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

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21 January 2018

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The ubiquitin system for protein degradation

21 January 2018

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

21 January 2018

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Monoubiquitin carries a novel internalization signal that is appended to activated receptors

21 January 2018

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Receptor downregulation and multivesicular-body sorting

21 January 2018

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Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain

21 January 2018

1 reference

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Noncovalent interaction between ubiquitin and the human DNA repair protein Mms2 is required for Ubc13-mediated polyubiquitination

21 January 2018

1 reference

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In vitro assembly and recognition of Lys-63 polyubiquitin chains

21 January 2018

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Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.

21 January 2018

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MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway

21 January 2018

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

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Parkin is associated with cellular vesicles

21 January 2018

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Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

21 January 2018

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Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

21 January 2018

1 reference

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Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

21 January 2018

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Attenuation of dopamine transporter activity by alpha-synuclein

21 January 2018

1 reference

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

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Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

21 January 2018

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Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein

21 January 2018

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Recognition of the polyubiquitin proteolytic signal

21 January 2018

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans

21 January 2018

1 reference

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Ubiquitin and the synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

A proteolytic pathway that recognizes ubiquitin as a degradation signal

21 January 2018

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A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Polar transmembrane domains target proteins to the interior of the yeast vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Mutations in the lipid-binding domain of α-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Regulation of neuronal function by protein trafficking: a role for the endosomal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

A Di-leucine Signal in the Ubiquitin Moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413591200

21 January 2018

Identifiers

DOI

10.1074/JBC.M413591200

1 reference

11 December 2017

1 reference