(Q45284384)

11 December 2017

title

Site-specific pseudophosphorylation modulates the rate of tau filament dissociation (English)

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11 December 2017

Mihaela Necula

1

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11 December 2017

Jeff Kuret

series ordinal

2

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11 December 2017

language of work or name

English

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publication date

1 February 2005

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11 December 2017

number of pages

5

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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11 December 2017

volume

579

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11 December 2017

issue

6

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11 December 2017

page(s)

1453-1457

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Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease.

11 December 2017

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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

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Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

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Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

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The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments

21 January 2018

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Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

21 January 2018

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Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

21 January 2018

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Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins.

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Evidence for an intermediate in tau filament formation

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Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro

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The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

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Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro

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21 January 2018

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21 January 2018

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The effects of Tubulin denaturation on the characterization of its polymerization behavior

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21 January 2018

Identifiers

DOI

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11 December 2017

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