(Q45300176)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28123081%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease (English)

1 reference

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9 April 2020

0 references

3

1 reference

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9 April 2020

Tatiana R. Rosenstock

4

1 reference

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9 April 2020

Ana I. Duarte

9

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9 April 2020

Michael R. Hayden

10

1 reference

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9 April 2020

Luana Naia

1

1 reference

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9 April 2020

Teresa Cunha-Oliveira

2

1 reference

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9 April 2020

Ana Oliveira

5

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9 April 2020

Catarina Carmo

7

1 reference

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9 April 2020

Ana Cristina Rego

11

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9 April 2020

author name string

Márcio Ribeiro

6

1 reference

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9 April 2020

Sofia I Oliveira-Sousa

8

1 reference

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9 April 2020

language of work or name

English

0 references

publication date

25 January 2017

1 reference

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9 April 2020

published in

Journal of Neuroscience

1 reference

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9 April 2020

volume

37

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9 April 2020

issue

10

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9 April 2020

page(s)

2776-2794

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28123081%20AND%20SRC:MED&resulttype=core&format=json

Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).

9 April 2020

cites work

1 reference

12 December 2020

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

1 reference

12 December 2020

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

1 reference

12 December 2020

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites

1 reference

12 December 2020

Regulation of the activity of the pyruvate dehydrogenase complex

1 reference

12 December 2020

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

1 reference

12 December 2020

Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency

1 reference

12 December 2020

Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity

1 reference

12 December 2020

Transcriptional abnormalities in Huntington disease

1 reference

12 December 2020

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

12 December 2020

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

12 December 2020

Characterization of the isozymes of pyruvate dehydrogenase phosphatase: implications for the regulation of pyruvate dehydrogenase activity.

1 reference

12 December 2020

Experimental therapeutics in transgenic mouse models of Huntington's disease

1 reference

12 December 2020

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

1 reference

12 December 2020

Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington disease

1 reference

12 December 2020

Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin

1 reference

12 December 2020

Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

1 reference

12 December 2020

ROS: really involved in oxygen sensing

1 reference

12 December 2020

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

1 reference

12 December 2020

In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets

1 reference

12 December 2020

Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

1 reference

12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 December 2020

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 December 2020

Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha

1 reference

12 December 2020

Regulation of the pyruvate dehydrogenase complex

1 reference

12 December 2020

Body weight is modulated by levels of full-length huntingtin

1 reference

12 December 2020

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

1 reference

12 December 2020

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

1 reference

12 December 2020

Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases

1 reference

12 December 2020

Regulation of the HIF-1alpha stability by histone deacetylases

1 reference

12 December 2020

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

1 reference

12 December 2020

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.

1 reference

12 December 2020

Regulation of protein turnover by acetyltransferases and deacetylases.

1 reference

12 December 2020

Sodium phenylbutyrate in Huntington's disease: a dose-finding study.

1 reference

12 December 2020

Mechanisms of neurodegeneration in Huntington's disease.

1 reference

12 December 2020

Mechanism of peroxide-induced cellular injury in cultured adult cardiac myocytes

1 reference

12 December 2020

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

1 reference

12 December 2020

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

1 reference

12 December 2020

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

1 reference

12 December 2020

Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

1 reference

12 December 2020

Monitoring phosphorylation of the pyruvate dehydrogenase complex.

1 reference

12 December 2020

Mitochondria in Huntington's disease

1 reference

12 December 2020

Acylcarnitines: role in brain.

1 reference

12 December 2020

Mitochondrial-dependent apoptosis in Huntington's disease human cybrids.

1 reference

12 December 2020

Regulation of cellular metabolism by protein lysine acetylation

1 reference

12 December 2020

Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism

1 reference

12 December 2020

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

1 reference

12 December 2020

PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle.

1 reference

12 December 2020

Energy deficit in Huntington disease: why it matters

1 reference

12 December 2020

Regulation of FoxO transcription factors by acetylation and protein-protein interactions

1 reference

12 December 2020

Bioenergetic dysfunction in Huntington's disease human cybrids.

1 reference

12 December 2020

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

1 reference

12 December 2020

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.

1 reference

12 December 2020

Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells.

1 reference

12 December 2020

Transcriptional regulation of pyruvate dehydrogenase kinase

1 reference

12 December 2020

Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic Huntington's disease carriers.

1 reference

12 December 2020

Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine

1 reference

12 December 2020

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

1 reference

12 December 2020

Current therapeutic advances in patients and experimental models of Huntington's disease.

1 reference

12 December 2020

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

1 reference

12 December 2020

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

1 reference

12 December 2020

Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington's disease knock-in striatal cells

1 reference

12 December 2020

Cerebral glucose consumption measured by PET in patients with and without psychiatric symptoms of Huntington's disease

1 reference

12 December 2020

Regulation of hypoxia-inducible factor-1a by reactive oxygen species: new developments in an old debate

1 reference

12 December 2020

Acetylation site specificities of lysine deacetylase inhibitors in human cells

1 reference

12 December 2020

HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons.

1 reference

12 December 2020

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin.

1 reference

12 December 2020

Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models

1 reference

12 December 2020

Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases

1 reference

12 December 2020

Cerebral metabolism and atrophy in huntington's disease determined by18FDG and computed tomographic scan

1 reference

12 December 2020

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1 reference

12 December 2020

Mitochondria: beyond oxidative phosphorylation

1 reference

12 December 2020

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

1 reference

12 December 2020

Regulation of the pyruvate dehydrogenase multienzyme complex

1 reference

12 December 2020

Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase

1 reference

12 December 2020

Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

1 reference

12 December 2020

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 December 2020

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

1 reference

12 December 2020

Histone acetylation and transcriptional regulatory mechanisms

1 reference

12 December 2020

1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

1 reference

12 December 2020

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

12 December 2020

Stabilization of the pyruvate dehydrogenase E1alpha subunit by dichloroacetate

1 reference

12 December 2020

10.1523/JNEUROSCI.2006-14.2016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28123081%20AND%20SRC:MED&resulttype=core&format=json

release_kuqefgph5zhi3a5g7w4q5suaki

9 April 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kuqefgph5zhi3a5g7w4q5suaki

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28123081%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PubMed publication ID

28123081

1 reference