(Q45306350)

11 December 2017

N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease (English)

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11 December 2017

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Rajat Sandhir

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11 December 2017

Aditi Sood

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2

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11 December 2017

Arpit Mehrotra

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3

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11 December 2017

Sukhdev S Kamboj

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4

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11 December 2017

language of work or name

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9 February 2012

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Neurodegenerative Diseases

11 December 2017

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11 December 2017

9

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11 December 2017

3

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11 December 2017

145-157

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

11 December 2017

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Mechanisms of neurodegeneration in Huntington's disease.

21 January 2018

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Selective neuronal degeneration in Huntington's disease

21 January 2018

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Striatal and extrastriatal atrophy in Huntington's disease and its relationship with length of the CAG repeat

21 January 2018

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N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

21 January 2018

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Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

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Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

21 January 2018

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

21 January 2018

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Recent advances in understanding the pathogenesis of Huntington's disease

21 January 2018

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Mitochondrial defect in Huntington's disease caudate nucleus

21 January 2018

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3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

21 January 2018

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Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease

21 January 2018

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Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

21 January 2018

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3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future.

21 January 2018

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Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

21 January 2018

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Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid

21 January 2018

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3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms.

21 January 2018

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Mitochondrial glutathione, a key survival antioxidant

21 January 2018

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Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review

21 January 2018

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Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases

21 January 2018

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Inhibition of mitochondrial respiratory chain in the brain of rats after renal ischemia is prevented by N-acetylcysteine and deferoxamine

21 January 2018

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Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease

21 January 2018

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Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury.

21 January 2018

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An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study

21 January 2018

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Studies on energy-linked reactions: modified mitochondrial ATPase of oligomycin-resistant mutants of Saccharomyces cerevisiae.

21 January 2018

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Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes

21 January 2018

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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

21 January 2018

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Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase

21 January 2018

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Cytochrome C is released from mitochondria into the cytosol after cerebral anoxia or ischemia.

21 January 2018

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Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonism

21 January 2018

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Utility of an elevated plus-maze for dissociation of amnesic and behavioral effects of drugs in mice

21 January 2018

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Neural mechanisms of ageing and cognitive decline

21 January 2018

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Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system

21 January 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

21 January 2018

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Energetics in the pathogenesis of neurodegenerative diseases

21 January 2018

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Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

21 January 2018

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Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats.

21 January 2018

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Mitochondria, oxygen free radicals, disease and ageing

21 January 2018

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Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid.

21 January 2018

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Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study

21 January 2018

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Increased formation of reactive oxygen species, but no changes in glutathione peroxidase activity, in striata of mice transgenic for the Huntington's disease mutation

21 January 2018

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N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage

21 January 2018

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N-acetylcysteine prevents mitochondria from oxidative injury induced by conventional peritoneal dialysate in human peritoneal mesothelial cells

21 January 2018

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Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach

21 January 2018

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The effects of stress and aging on glutathione metabolism

21 January 2018

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Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy

21 January 2018

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Invited review: manganese superoxide dismutase in disease

21 January 2018

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N-acetylcysteine increases manganese superoxide dismutase activity in septic rat diaphragms

21 January 2018

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Basal ganglia degeneration, myelin alterations, and enzyme inhibition induced in mice by the plant toxin 3-nitropropanoic acid

21 January 2018

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

21 January 2018

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Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis

21 January 2018

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Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.

21 January 2018

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Mitochondrial control of cell death

21 January 2018

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Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity.

21 January 2018

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FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

21 January 2018

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Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species.

21 January 2018

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Watching the watcher: regulation of p53 by mitochondria

21 January 2018

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p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

21 January 2018

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

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Role of HSP27 and reduced glutathione in modulating malathion-induced apoptosis of human peripheral blood mononuclear cells: ameliorating effect of N-acetylcysteine and curcumin.

21 January 2018

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Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: involvement of ERK and p38 phosphorylation

21 January 2018

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Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid

21 January 2018

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Lipid peroxidation associated cardiolipin loss and membrane depolarization in rat brain mitochondria

21 January 2018

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Perseverative behavior underlying attentional set-shifting deficits in rats chronically treated with the neurotoxin 3-nitropropionic acid.

21 January 2018

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Behavioral and biochemical effects of glutathione depletion in the rat brain

21 January 2018

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N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia

21 January 2018

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N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium

21 January 2018

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Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis

21 January 2018

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Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

21 January 2018

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Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats

21 January 2018

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Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.

21 January 2018

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Correlation of morphologic brain lesions with physiologic alterations and blood-brain barrier impairment in 3-nitropropionic acid toxicity in rats.

21 January 2018

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Reactive oxygen species and the central nervous system

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000334273

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11 December 2017

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