(Q45318082)

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VEGFA-VEGFR2 Pathway

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-4420097)

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https://identifiers.org/reactome:R-HSA-4420097

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VEGFR2 mediated vascular permeability

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VEGFR2 mediated cell proliferation

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PI(3,4,5)P3 binds VAV1,2,3

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RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)

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p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3

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VEGFR2 autophosphorylates

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p-6Y-VEGFR2 binds SHB

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SRC-1 phosphorylates SHB

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PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2

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PTK2 autophosphorylates

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SRC-1 binds p-Y397-PTK2

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SRC-1 phosphorylates p-Y397-PTK2

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Integrin alphaVbeta3 binds p-6Y-VEGFR2

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HSP90AA1 binds p-6Y-VEGFR2

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RHOA:GTP:Mg2+ binds ROCK1,ROCK2

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ROCK1,ROCK2 are activated

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Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

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PTK2beta binds alphaVbeta3

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SRC-1 phosphorylates PTK2-beta

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p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407

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PXN binds p-6Y,S732-PTK2

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PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

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BCAR1 binds p-7Y-PTK2

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PTK2/SRC-1 phosphorylates BCAR1

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CRK binds BCAR1 and or PXN

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DOCK180:ELMO binds CRK

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p-6Y-VEGFR2 binds SHC-transforming protein 2

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p-6Y-VEGFR2 binds SH2D2A

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DOCK180:ELMO exchanges GTP for GDP, activating RAC1

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SRC1-1 binds SH2D2A and is recruited to VEGFR2

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Phosphorylation of SRC-1

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AXL autophosphorylates on Y772 and Y814

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p-6Y-VEGFR2 binds PI3K

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VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3

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Src kinases phosphorylate VAV

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p-VAV family:PIP3 binds RAC1:GDP

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NADPH oxidase 2 (NOX2) complex binds RAC1

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NADPH oxidase 2 generates superoxide from oxygen

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p-6Y-VEGFR2 binds NCK

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p-6Y-VEGFR2 binds FYN

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FYN autophosphorylates

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p-Y420-FYN is phosphorylated on S21

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VEGF induces CDC42 activation by unknown mechanism

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FYN phosphorylates PAK2

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p38 MAPK activation by VEGFR

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p-MAPK2/3 phosphorylates HSP27

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VAV exchanges GTP for GDP on RAC1, activating it

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VEGFA-165 dimer binds VEGFR2 dimer

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VEGFA-165 dimer binds VEGFA inhibitors

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VEGF-receptor signal transduction

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8 July 2022

Vascular endothelial growth factor family of ligands and receptors: review

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VEGF receptor signalling - in control of vascular function

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VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

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8 July 2022

Identifiers

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8 July 2022

(Q45318082)

VEGFA-VEGFR2 Pathway

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