(Q45318326)

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Signaling by PTK6

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8848021)

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8 July 2022

Signaling by Non-Receptor Tyrosine Kinases

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https://identifiers.org/reactome:R-HSA-8848021

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ERBB2 Activates PTK6 Signaling

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PTK6 Regulates Cell Cycle

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PTK6 Regulates Proteins Involved in RNA Processing

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PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

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PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

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PTK6 promotes HIF1A stabilization

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STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

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Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

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Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

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Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR

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Brk is coamplified with ErbB2 to promote proliferation in breast cancer

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PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1

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Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4

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Tracing the footprints of the breast cancer oncogene BRK - Past till present

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Regulated association of protein kinase B/Akt with breast tumor kinase

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Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

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Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

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8 July 2022

Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

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Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells

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BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

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Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

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Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.

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Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms

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Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

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Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.

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Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

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Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor

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Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

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PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling

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Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

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Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification

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8 July 2022

Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

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8 July 2022

Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

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8 July 2022

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

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8 July 2022

The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

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PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

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Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.

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Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration

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8 July 2022

Identifiers

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8 July 2022

(Q45318326)

Signaling by PTK6

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