(Q45368304)

13 December 2017

title

Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation (English)

1 reference

13 December 2017

0 references

5

Jens Waschke

1 reference

13 December 2017

4

Norbert Roewer

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13 December 2017

author name string

Martin Alexander Schick

1

1 reference

13 December 2017

Christian Wunder

2

1 reference

13 December 2017

Jakob Wollborn

3

1 reference

13 December 2017

Christoph-Thomas Germer

6

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13 December 2017

Nicolas Schlegel

7

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13 December 2017

language of work or name

English

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publication date

10 April 2012

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13 December 2017

number of pages

16

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inferred from page(s)

published in

Journal of Physiology

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13 December 2017

volume

590

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13 December 2017

issue

11

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13 December 2017

page(s)

2693-2708

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Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume-expanded mice

13 December 2017

cites work

1 reference

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Phosphodiesterase 4 inhibition attenuates atrial natriuretic peptide-induced vascular hyperpermeability and loss of plasma volume

27 August 2018

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Role of GTPases in control of microvascular permeability

27 August 2018

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27 August 2018

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27 August 2018

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The impact of crystalloid and colloid infusion on the kidney in rodent sepsis

27 August 2018

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Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability.

27 August 2018

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Impaired cAMP and Rac 1 signaling contribute to TNF-alpha-induced endothelial barrier breakdown in microvascular endothelium.

27 August 2018

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27 August 2018

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Lipopolysaccharide-induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro

27 August 2018

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Urodilatin and pentoxifylline prevent the early onset of Escherichia coli-induced acute renal failure in a model of isolated perfused rat kidney

27 August 2018

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VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells

27 August 2018

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Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia

27 August 2018

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Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

27 August 2018

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Regulation of endothelial junctional permeability

27 August 2018

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Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery

27 August 2018

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Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection

27 August 2018

1 reference

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The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization

27 August 2018

1 reference

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Advances in pathogenesis and management of sepsis

27 August 2018

1 reference

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Serum lactate as a predictor of mortality in patients with infection

27 August 2018

1 reference

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Novel therapies for microvascular permeability in sepsis

27 August 2018

1 reference

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LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression

27 August 2018

1 reference

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The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects

27 August 2018

1 reference

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Rodent models of intra-abdominal infection

27 August 2018

1 reference

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Signaling mechanisms regulating endothelial permeability

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Lipopolysaccharide signaling in endothelial cells

27 August 2018

1 reference

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Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

27 August 2018

1 reference

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Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

27 August 2018

1 reference

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Vascular endothelial cell cyclic nucleotide phosphodiesterases and regulated cell migration: implications in angiogenesis

27 August 2018

1 reference

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Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

27 August 2018

1 reference

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cAMP protects endothelial barrier functions by preventing Rac-1 inhibition

27 August 2018

1 reference

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Effects of dopamine, dobutamine, and dopexamine on microcirculatory blood flow in the gastrointestinal tract during sepsis and anesthesia

27 August 2018

1 reference

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Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitro

27 August 2018

1 reference

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Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly

27 August 2018

1 reference

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Pharmacokinetics and pharmacodynamics of intravenous inotropic agents

27 August 2018

1 reference

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Requirement of Rac activity for maintenance of capillary endothelial barrier properties

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Differential effects of amrinone and milrinone upon myocardial inflammatory signaling.

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Inhibition of haem oxygenase activity increases leukocyte accumulation in the liver following limb ischaemia-reperfusion in mice

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Toll-like receptors and innate immunity

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

The endothelium in sepsis: source of and a target for inflammation

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Base deficit development and its prognostic significance in posttrauma critical illness: an analysis by the trauma registry of the Deutsche Gesellschaft für unfallchirurgie

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Regulation of endothelial barrier function by the cAMP-dependent protein kinase.

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

The acute respiratory distress syndrome

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Microvascular permeability and number of tight junctions are modulated by cAMP.

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Survival probabilities (the Kaplan-Meier method).

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Mathematical models of capillary flow: a critical review.

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Analysis of microvascular permeability to macromolecules by video-image digital processing

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Effects of propranolol on myocardial performance during acute normovolemic hemodilution

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424725

Sepsis and Endothelial Permeability

27 August 2018

1 reference

12 December 2020

Inhibition of cytokine release by and cardiac effects of type IV phosphodiesterase inhibition in early, profound endotoxaemia in vivo

1 reference

12 December 2020

The effects of sepsis on gut mucosal blood flow in rats

1 reference

12 December 2020

Demonstration of actin filament stress fibers in microvascular endothelial cells in situ

1 reference

12 December 2020

TNF modulates endothelial properties by decreasing cAMP

1 reference

12 December 2020

Inhibition of type IV phosphodiesterase by Ro 20-1724 attenuates endotoxin-induced acute renal failure

1 reference

12 December 2020

10.1113/JPHYSIOL.2012.232116

Identifiers

DOI

1 reference

13 December 2017

0 references

1 reference