(Q45415437)

English

Effect of plasma protein binding on elimination of taurocholate by isolated perfused rat liver: comparison of venous equilibrium, undistributed and distributed sinusoidal, and dispersion models

scientific article published in August 1988

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

Effect of plasma protein binding on elimination of taurocholate by isolated perfused rat liver: comparison of venous equilibrium, undistributed and distributed sinusoidal, and dispersion models (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

author name string

R H Smallwood

1

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

D J Morgan

2

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

G W Mihaly

3

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

D B Jones

4

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

R A Smallwood

5

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

publication date

1 August 1988

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

Journal of Pharmacokinetics and Pharmacodynamics

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

16

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

377-396

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

https://scigraph.springernature.com/pub.10.1007/bf01062552

0 references

Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ pr

1 reference

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On the uptake of materials by the intact liver. The transport and net removal of galactose

1 reference

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Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system

1 reference

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Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1 reference

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21 January 2018

Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

1 reference

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21 January 2018

Albumin helps mediate removal of taurocholate by rat liver

1 reference

https://api.crossref.org/works/10.1007%2FBF01062552

21 January 2018

Hepatic elimination of flowing substrates: the distributed model

1 reference

https://api.crossref.org/works/10.1007%2FBF01062552

21 January 2018

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

1 reference

https://api.crossref.org/works/10.1007%2FBF01062552

21 January 2018

Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT

1 reference

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Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

1 reference

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21 January 2018

Protein binding and hepatic clearance: discrimination between models of hepatic clearance with diazepam, a drug of high intrinsic clearance, in the isolated perfused rat liver preparation.

1 reference

https://api.crossref.org/works/10.1007%2FBF01062552

21 January 2018

Flow dependence of first-order uptake of substances by heterogeneous perfused organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

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Modeling of substrate elimination by the liver: has the albumin receptor model superseded the well-stirred model?

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

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Use of unbound drug concentration in blood to discriminate between two models of hepatic drug elimination

1 reference

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Hepatocytes of Zones 1 and 3 conjugate sulfobromophthalein with glutathione

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Effects of saturating metabolic uptake on space profiles and tracer kinetics

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Evidence favoring the venous equilibrium model for hepatic clearance of (S)-(--)-propranolol

1 reference

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Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver

1 reference

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Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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Transport of fluorescent compounds into hepatocytes and the resultant zonal labeling of the hepatic acinus in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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Current models of hepatic pharmacokinetics: flow effects on kinetic constants of ethanol elimination in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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based on heuristic

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Albumin does not mediate the removal of taurocholate by the rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Canalicular bile formation in the isolated perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol elimination kinetics in human liver and pig liver in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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Uptake of monohydric alcohols by liver: demonstration of a shared enzymic space

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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Heterogeneous intrahepatic distribution of blood flow in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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based on heuristic

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Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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based on heuristic

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Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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Effects of unstirred Disse fluid, nonequilibrium binding, and surface-mediated dissociation on hepatic removal of albumin-bound organic anions

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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Lumpers vs. distributers

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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Autoradiographic evidence for hepatic lobular concentration gradient of bile acid derivative.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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The terminal hepatic microcirculation in the rat

1 reference

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Hepatic galactose elimination kinetics in the intact pig.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

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based on heuristic

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Variation in hepatic extraction ratio with unbound drug fraction: discrimination between models of hepatic drug elimination.

1 reference

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The hepatic sinusoid is not well-stirred: estimation of the degree of axial mixing by analysis of lobular concentration gradients formed during uptake of thyroxine by the perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

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Hepatic transport kinetics and plasma disappearance curves: distributed modeling versus conventional approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

based on heuristic

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Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic uptake of propranolol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3193365

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01062552

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 December 2017

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