(Q45848384)

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Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials

scientific article published on 3 August 2017

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scholarly article

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials (English)

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

endometrial cancer

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based on heuristic

inferred from title

Nicolas Wentzensen

10

object named as

Nicolas Wentzensen

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Europe PubMed Central

16 December 2017

Kenneth P Nephew

9

object named as

Kenneth P Nephew

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

author name string

Helen J MacKay

1

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Douglas A Levine

2

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Victoria L Bae-Jump

3

1 reference

Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Daphne W Bell

4

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Jessica N McAlpine

5

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16 December 2017

http://europepmc.org/abstract/PMC/5663622

Alessandro Santin

6

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Gini F Fleming

7

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

David G Mutch

8

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Paul J Goodfellow

11

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Oliver Dorigo

12

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Hans W Nijman

13

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Russell Broaddus

14

1 reference

Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

Elise C Kohn

15

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3 August 2017

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Europe PubMed Central

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8

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Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

48

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Europe PubMed Central

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http://europepmc.org/abstract/PMC/5663622

84579-84594

1 reference

Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

The 'Pushmi-Pullyu' of DNA REPAIR: Clinical Synthetic Lethality

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24 May 2018

Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing.

1 reference

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24 May 2018

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition

1 reference

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24 May 2018

A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).

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24 May 2018

In-depth molecular profiling of the biphasic components of uterine carcinosarcomas

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24 May 2018

Regression of Chemotherapy-Resistant Polymerase ε (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

1 reference

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24 May 2018

Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study

1 reference

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24 May 2018

Targeting EZH2 in cancer

1 reference

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24 May 2018

Measuring the biological effect of presurgical metformin treatment in endometrial cancer.

1 reference

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24 May 2018

Cancer statistics, 2016

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24 May 2018

Predictive Modeling: A New Paradigm for Managing Endometrial Cancer

1 reference

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24 May 2018

Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo

1 reference

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24 May 2018

PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas

1 reference

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24 May 2018

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer

1 reference

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24 May 2018

Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1

1 reference

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24 May 2018

A clinically applicable molecular-based classification for endometrial cancers

1 reference

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24 May 2018

The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer

1 reference

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24 May 2018

Randomized Phase II Trial of Ridaforolimus in Advanced Endometrial Carcinoma

1 reference

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24 May 2018

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

1 reference

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24 May 2018

In Vitro Validation of Survivin as Target Tumor-associated Antigen for Immunotherapy in Uterine Cancer.

1 reference

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24 May 2018

POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

1 reference

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24 May 2018

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover

1 reference

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24 May 2018

Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma

1 reference

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24 May 2018

HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant

1 reference

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24 May 2018

Metabolic syndrome and risk of endometrial cancer in the united states: a study in the SEER-medicare linked database

1 reference

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24 May 2018

Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells

1 reference

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24 May 2018

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

1 reference

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24 May 2018

Role of the ubiquitin proteasome system in hematologic malignancies.

1 reference

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24 May 2018

Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer.

1 reference

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24 May 2018

SCF ubiquitin ligase-targeted therapies.

1 reference

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24 May 2018

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities

1 reference

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24 May 2018

Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma

1 reference

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24 May 2018

Molecular alterations of PIK3CA in uterine carcinosarcoma, clear cell, and serous tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Effects of metformin on endometrial cancer cell growth in vivo: a preoperative prospective trial

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24 May 2018

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

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24 May 2018

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

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24 May 2018

Recent and current Phase II clinical trials in endometrial cancer: review of the state of art.

1 reference

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24 May 2018

HER2 immunohistochemistry significantly overestimates HER2 amplification in uterine papillary serous carcinomas

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24 May 2018

Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells

1 reference

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24 May 2018

HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges

1 reference

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24 May 2018

Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: a gynecologic oncology group study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Metformin--mode of action and clinical implications for diabetes and cancer

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24 May 2018

Metformin is associated with improved survival in endometrial cancer

1 reference

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24 May 2018

Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer

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24 May 2018

New strategies in endometrial cancer: targeting the PI3K/mTOR pathway--the devil is in the details

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24 May 2018

Epigenetic modification restores functional PR expression in endometrial cancer cells

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24 May 2018

Integrated genomic characterization of endometrial carcinoma

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24 May 2018

Poor interobserver reproducibility in the diagnosis of high-grade endometrial carcinoma

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24 May 2018

Everolimus as second- or third-line treatment of advanced endometrial cancer: ENDORAD, a phase II trial of GINECO.

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24 May 2018

HER2 expression beyond breast cancer: therapeutic implications for gynecologic malignancies

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24 May 2018

Phase II study of fulvestrant 250 mg/month in patients with recurrent or metastatic endometrial cancer: a study of the Arbeitsgemeinschaft Gynäkologische Onkologie

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24 May 2018

Ridaforolimus as a single agent in advanced endometrial cancer: results of a single-arm, phase 2 trial.

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24 May 2018

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

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24 May 2018

WNT signalling pathways as therapeutic targets in cancer

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24 May 2018

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

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24 May 2018

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.

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24 May 2018

The genomics and genetics of endometrial cancer

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24 May 2018

Lapatinib and potential prognostic value of EGFR mutations in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer

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24 May 2018

Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer

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24 May 2018

Differential analysis of ovarian and endometrial cancers identifies a methylator phenotype

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24 May 2018

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

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24 May 2018

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

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24 May 2018

Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumab

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24 May 2018

PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer

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24 May 2018

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers

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24 May 2018

A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas

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24 May 2018

Hormonal therapy in advanced or recurrent endometrial cancer

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24 May 2018

Phase II study of fulvestrant in recurrent/metastatic endometrial carcinoma: a Gynecologic Oncology Group study

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24 May 2018

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors

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24 May 2018

ARID1A mutations in endometriosis-associated ovarian carcinomas

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24 May 2018

DNA methylation in endometrial cancer

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24 May 2018

Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group study

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24 May 2018

Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy

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24 May 2018

Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma.

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24 May 2018

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

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24 May 2018

Current treatment of metastatic endometrial cancer

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24 May 2018

Wnt signalling and its impact on development and cancer

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24 May 2018

Metformin and reduced risk of cancer in diabetic patients

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24 May 2018

Hormonal therapy of endometrial cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

The role of p16-cyclin d/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Cdc2 regulatory factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

24 May 2018

Refining prognosis and identifying targetable pathways for high-risk endometrial cancer; a TransPORTEC initiative.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Targeted mutation analysis of endometrial clear cell carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Wilms' Tumor Gene 1 (WT1)--loaded dendritic cell immunotherapy in patients with uterine tumors: a phase I/II clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Histotype-genotype correlation in 36 high-grade endometrial carcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Immunofluorescence-detected infiltration of CD4+FOXP3+ regulatory T cells is relevant to the prognosis of patients with endometrial cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Letter to the Editor referring to the manuscript entitled: "Phase II trial of trastuzumab in women with advanced or recurrent HER-positive endometrial carcinoma: a Gynecologic Oncology Group study" recently reported by Fleming et al., (Gynecol Oncol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663622

15 August 2018

Immunohistochemical expression of E-cadherin and beta-catenin in the normal and malignant human endometrium: an inverse correlation between E-cadherin and nuclear beta-catenin expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of undifferentiated carcinoma associated with endometrioid carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of trastuzumab in the treatment of metastatic endometrial cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-Catenin mutations in recurrent FIGO IA grade I endometrioid endometrial cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of CD3+ tumor-infiltrating lymphocytes in patients with endometrial carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical expression of cyclins, cyclin-dependent kinases, tumor-suppressor gene products, Ki-67, and sex steroid receptors in endometrial carcinoma: positive staining for cyclin A as a poor prognostic indicator

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus is a multivariate independent prognostic factor in endometrial carcinoma: a clinicopathologic study on 313 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of potential therapeutic targets by molecular profiling of 628 cases of uterine serous carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29137450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.19961

1 reference

Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

1 reference

Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

1 reference

Europe PubMed Central

16 December 2017

http://europepmc.org/abstract/PMC/5663622

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