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SCF ubiquitin ligase-targeted therapies.
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Europe PubMed Central
PMC publication ID
4410837
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
review article
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Europe PubMed Central
title
SCF ubiquitin ligase-targeted therapies
(English)
1 reference
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Europe PubMed Central
PMC publication ID
4410837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
author
Julia K Pagan
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2
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Europe PubMed Central
PMC publication ID
4410837
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
Michele Pagano
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3
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Europe PubMed Central
PMC publication ID
4410837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
author name string
Jeffrey R Skaar
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1
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Europe PubMed Central
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4410837
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
publication date
14 November 2014
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4410837
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22 February 2020
published in
Nature Reviews Drug Discovery
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stated in
Europe PubMed Central
PMC publication ID
4410837
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22 February 2020
volume
13
1 reference
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Europe PubMed Central
PMC publication ID
4410837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
issue
12
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Europe PubMed Central
PMC publication ID
4410837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
page(s)
889-903
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Europe PubMed Central
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4410837
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retrieved
22 February 2020
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F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation
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6 September 2017
Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells
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6 September 2017
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
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Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor
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6 September 2017
F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest
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Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.
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Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
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6 September 2017
Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues
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6 September 2017
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6 September 2017
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6 September 2017
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
Teratogenic effects of thalidomide: molecular mechanisms
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6 September 2017
Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells
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6 September 2017
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells
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6 September 2017
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation
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6 September 2017
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6 September 2017
Identification of a primary target of thalidomide teratogenicity
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6 September 2017
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant
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6 September 2017
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6 September 2017
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
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6 September 2017
Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa
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6 September 2017
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6 September 2017
Identification of retinoic acid-regulated nuclear matrix-associated protein as a novel regulator of gastric cancer.
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6 September 2017
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6 September 2017
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
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6 September 2017
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
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6 September 2017
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6 September 2017
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
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6 September 2017
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6 September 2017
FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome
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6 September 2017
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6 September 2017
Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
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6 September 2017
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
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6 September 2017
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
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6 September 2017
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
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6 September 2017
Activating the ubiquitin family: UBA6 challenges the field
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6 September 2017
Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
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6 September 2017
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
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6 September 2017
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway
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6 September 2017
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
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6 September 2017
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
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6 September 2017
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
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6 September 2017
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
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6 September 2017
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
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6 September 2017
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
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6 September 2017
Mechanism of auxin perception by the TIR1 ubiquitin ligase
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6 September 2017
MDM2 inhibitors for cancer therapy
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6 September 2017
Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma
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6 September 2017
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.
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6 September 2017
Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase
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6 September 2017
High-throughput screening for inhibitors of the Cks1-Skp2 interaction
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6 September 2017
A genomic and functional inventory of deubiquitinating enzymes
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6 September 2017
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
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6 September 2017
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication
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6 September 2017
Flavopiridol, an inhibitor of transcription: implications, problems and solutions
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6 September 2017
Systematic analysis and nomenclature of mammalian F-box proteins
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6 September 2017
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
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6 September 2017
The SCF ubiquitin ligase: insights into a molecular machine
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6 September 2017
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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6 September 2017
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation
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6 September 2017
Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
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6 September 2017
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
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6 September 2017
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27
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6 September 2017
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6 September 2017
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
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6 September 2017
c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells
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6 September 2017
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
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6 September 2017
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
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6 September 2017
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
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6 September 2017
The ubiquitin system
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6 September 2017
A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.
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6 September 2017
WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells
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6 September 2017
Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.
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6 September 2017
MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL.
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6 September 2017
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma
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6 September 2017
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14 September 2017
Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.
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14 September 2017
Will the ubiquitin system furnish as many drug targets as protein kinases?
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4410837
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14 September 2017
An auxin-based degron system for the rapid depletion of proteins in nonplant cells.
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14 September 2017
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
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14 September 2017
Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells
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14 September 2017
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.
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14 September 2017
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.
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14 September 2017
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
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14 September 2017
Bioluminescent imaging of Cdk2 inhibition in vivo
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14 September 2017
Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation
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14 September 2017
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
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27 September 2017
Antiviral treatment of hepatitis C.
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23 June 2018
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
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23 June 2018
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
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23 June 2018
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma
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31 August 2018
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
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31 August 2018
FBXW7/hCDC4 is a general tumor suppressor in human cancer.
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31 August 2018
Skp2-mediated degradation of p27 regulates progression into mitosis
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31 August 2018
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
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31 August 2018
Ubiquitin-based anticancer therapy: carpet bombing with proteasome inhibitors vs surgical strikes with E1, E2, E3, or DUB inhibitors
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31 March 2020
SnapShot: F Box Proteins II
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31 March 2020
Macrocerebellum, epilepsy, intellectual disability, and gut malrotation in a child with a 16q24.1-q24.2 contiguous gene deletion
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31 March 2020
A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated factor 1
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31 March 2020
A novel small-molecule inhibitor of NF-kappaB signaling
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31 March 2020
c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Inhibition of homologue of Slimb (HOS) function sensitizes human melanoma cells for apoptosis
1 reference
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https://pubmed.ncbi.nlm.nih.gov/25394868
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NRD4432
1 reference
stated in
Europe PubMed Central
PMC publication ID
4410837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
PMC publication ID
4410837
1 reference
stated in
Europe PubMed Central
PMC publication ID
4410837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PubMed publication ID
25394868
1 reference
stated in
Europe PubMed Central
PMC publication ID
4410837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394868%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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