(Q37240152)

English

Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer

scientific article published on 13 September 2013

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scholarly article

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21 February 2020

Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer (English)

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21 February 2020

endometrial cancer

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21 February 2020

author name string

Savvas C Pavlides

1

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21 February 2020

Kuang-Tzu Huang

2

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21 February 2020

Dylan A Reid

3

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21 February 2020

Lily Wu

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Stephanie V Blank

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21 February 2020

Khushbakhat Mittal

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Lankai Guo

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21 February 2020

Bo Rueda

9

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21 February 2020

Timothy Cardozo

10

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21 February 2020

Leslie I Gold

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13 September 2013

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21 February 2020

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21 February 2020

154

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11

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21 February 2020

4030-4045

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21 February 2020

describes a project that uses

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11 June 2022

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Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

1 reference

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High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1

1 reference

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Changes in Psp protein binding partners, localization and behaviour upon activation of the Yersinia enterocolitica phage shock protein response

1 reference

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Specific small molecule inhibitors of Skp2-mediated p27 degradation

1 reference

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1 reference

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6 September 2017

Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

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1 reference

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Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization

1 reference

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6 September 2017

Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer

1 reference

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6 September 2017

Direct stochastic optical reconstruction microscopy with standard fluorescent probes

1 reference

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6 September 2017

High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

1 reference

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6 September 2017

p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.

1 reference

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Mantle cell lymphoma in relapse: the role of emerging new drugs.

1 reference

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QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

p27 as Jekyll and Hyde: regulation of cell cycle and cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Ubiquitin-mediated control of oncogene and tumor suppressor gene products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Endometrial hyperplasia and the risk of progression to carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

Proteasome inhibitors in cancer therapy: lessons from the first decade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800755

6 September 2017

A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer

1 reference

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6 September 2017

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes

1 reference

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6 September 2017

Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma

1 reference

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6 September 2017

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

1 reference

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

1 reference

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1 reference

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Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

1 reference

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6 September 2017

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1 reference

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6 September 2017

Focus on endometrial and cervical cancer

1 reference

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6 September 2017

Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

1 reference

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6 September 2017

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

1 reference

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Skp2 is oncogenic and overexpressed in human cancers

1 reference

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1 reference

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The ubiquitin system

1 reference

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Hyperplasia and carcinoma of the endometrium.

1 reference

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6 September 2017

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1 reference

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1 reference

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14 September 2017

TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest

1 reference

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14 September 2017

Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry

1 reference

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14 September 2017

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1 reference

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28 September 2017

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1 reference

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1 reference

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1 reference

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3 September 2018

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1 reference

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3 September 2018

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1 reference

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3 September 2018

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1 reference

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3 September 2018

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1 reference

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3 September 2018

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1 reference

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3 September 2018

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1 reference

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3 September 2018

Single-molecule FRET analysis of helicase functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/24035998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24035998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/EN.2013-1757

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Europe PubMed Central

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21 February 2020

1 reference

Europe PubMed Central

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21 February 2020

1 reference

Europe PubMed Central

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21 February 2020

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