(Q48287164)

10 February 2018

title

Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro. (English)

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10 February 2018

author

Arnaud Besson

7

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10 February 2018

author name string

M P Serres

1

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10 February 2018

E Zlotek-Zlotkiewicz

2

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10 February 2018

C Concha

3

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10 February 2018

M Gurian-West

4

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10 February 2018

V Daburon

5

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10 February 2018

J M Roberts

6

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10 February 2018

language of work or name

English

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publication date

14 February 2011

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10 February 2018

published in

Oncogene

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10 February 2018

volume

30

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10 February 2018

issue

25

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10 February 2018

page(s)

2846-2858

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10 February 2018

https://scigraph.springernature.com/pub.10.1038/onc.2011.9

exact match

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cites work

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A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

21 January 2018

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p27Kip1 modulates cell migration through the regulation of RhoA activation.

21 January 2018

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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

21 January 2018

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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

21 January 2018

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

21 January 2018

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Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors

21 January 2018

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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

21 January 2018

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma

21 January 2018

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Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.9

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 January 2018

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.9

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

21 January 2018

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

21 January 2018

1 reference

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Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

21 January 2018

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Identification of CDK4 as a target of c-MYC.

21 January 2018

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mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation

21 January 2018

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Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Identification of bronchioalveolar stem cells in normal lung and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Cyclin D1 induction of cellular migration requires p27(KIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Mouse models for human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.9

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.9

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10 February 2018

Dimensions Publication ID

1029697569

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1 reference

10 February 2018