(Q38201970)

30 August 2017

New insights into ubiquitin E3 ligase mechanism (English)

1 reference

30 August 2017

Christopher E. Berndsen

object named as

Christopher E Berndsen

series ordinal

1

0 references

Cynthia Wolberger

object named as

Cynthia Wolberger

series ordinal

2

0 references

publication date

1 April 2014

1 reference

Nature Structural & Molecular Biology

30 August 2017

1 reference

30 August 2017

21

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30 August 2017

4

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30 August 2017

301-307

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.2780

30 August 2017

0 references

cites work

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RINGs hold the key to ubiquitin transfer

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Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

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An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2.Ubc13. The structural basis for lysine 63 chain catalysis

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

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BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

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E2 interaction and dimerization in the crystal structure of TRAF6

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31 March 2020

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Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

31 March 2020

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31 March 2020

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31 March 2020

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E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer

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E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

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Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

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INTRAMOLECULAR MODELS DEPICTING THE KINETIC IMPORTANCE OF "FIT" IN ENZYMATIC CATALYSIS.

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Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate

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Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78

31 March 2020

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A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination

31 March 2020

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Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine

31 March 2020

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Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

31 March 2020

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A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms

31 March 2020

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Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

31 March 2020

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Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

31 March 2020

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Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

31 March 2020

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Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

31 March 2020

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Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

31 March 2020

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E6AP/UBE3A ubiquitin ligase harbors two E2~ubiquitin binding sites

31 March 2020

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Polyubiquitination by HECT E3s and the determinants of chain type specificity

31 March 2020

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The role of parkin in familial and sporadic Parkinson's disease

31 March 2020

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UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

31 March 2020

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Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

31 March 2020

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Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

31 March 2020

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Structure of parkin reveals mechanisms for ubiquitin ligase activation

31 March 2020

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Structure of the human Parkin ligase domain in an autoinhibited state

31 March 2020

1 reference

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

31 March 2020

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A ubiquitin ligase complex assembles linear polyubiquitin chains

31 March 2020

1 reference

Autoregulation of Parkin activity through its ubiquitin-like domain

31 March 2020

1 reference

Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.

31 March 2020

1 reference

Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways

31 March 2020

1 reference

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway

31 March 2020

1 reference

Regulation of Parkin E3 ubiquitin ligase activity.

31 March 2020

1 reference

Breaking the chains: structure and function of the deubiquitinases

31 March 2020

1 reference

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

31 March 2020

1 reference

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

31 March 2020

1 reference

Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements.

31 March 2020

1 reference

Structure of ubiquitin refined at 1.8 A resolution

31 March 2020

1 reference

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

31 March 2020

1 reference

The Structure and Conformation of Lys63-Linked Tetraubiquitin

31 March 2020

1 reference

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

31 March 2020

1 reference

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

31 March 2020

1 reference

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

31 March 2020

1 reference

Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins

31 March 2020

1 reference

PubMed

12 December 2020

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway

1 reference

PubMed

12 December 2020

Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2)

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/NSMB.2780

1 reference

PubMed ID

24699078

Dimensions Publication ID

30 August 2017

0 references

1 reference

PubMed ID

24699078