(Q45857343)

17 December 2017

title

A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury (English)

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17 December 2017

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2

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17 December 2017

author name string

K Löw

series ordinal

1

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17 December 2017

J Herrmann

series ordinal

3

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17 December 2017

M H Tuszynski

series ordinal

4

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17 December 2017

publication date

4 March 2010

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

17

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17 December 2017

issue

5

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17 December 2017

page(s)

577-591

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17 December 2017

Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination.

cites work

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Chondroitinase ABC promotes functional recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Regeneration of adult axons in white matter tracts of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

RGMa inhibition promotes axonal growth and recovery after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Netrin-1 is a novel myelin-associated inhibitor to axon growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

The transcription factor ATF-3 promotes neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Targeting brain stem centers of cardiovascular control using adenoviral vectors: impact of promoters on transgene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Targeted transgene expression in rat brain using lentiviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

False resurrections: distinguishing regenerated from spared axons in the injured central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Repulsive Wnt signaling inhibits axon regeneration after CNS injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Chemotropic guidance of developing axons in the mammalian central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through enabled and, in parallel, Rac and UNC-115/AbLIM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Generalized lacZ expression with the ROSA26 Cre reporter strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Activation of FAK and Src are receptor-proximal events required for netrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Focal adhesion kinase in netrin-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

N-terminal domain of Borna disease virus G (p56) protein is sufficient for virus receptor recognition and cell entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Evaluation of epitope tags for protein detection after in vivo CNS gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

7 January 2021

Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

7 January 2021

Axonal Regeneration through Regions of Chondroitin Sulfate Proteoglycan Deposition after Spinal Cord Injury: A Balance of Permissiveness and Inhibition

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

7 January 2021

A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

7 January 2021

Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

7 January 2021

Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

7 January 2021

NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.14

7 January 2021

Identifiers

DOI

10.1038/GT.2010.14

1 reference

17 December 2017

Dimensions Publication ID

1014748586

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1 reference

17 December 2017